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  • ISSN: 2373-9371
    Volume 5, Issue 3
    Research Article
    Hidetoshi Takahashi*, Masaru Honma, Katsuhiko Satoh, Akiyoshi Takagi, Akemi Ishida-Yamamoto, and Hajime Iizuka
    Background: Topical application of 1a, 25-dihydroxyvitamin D3 (1-a,25-(OH)2D3) inhibits7, 12-dimethylbenz [a] anthracene (DMBA) and 12-a-tetradecanoylphorbol-13-acetate (TPA)-induced tumor formation of mouse skin. Ultraviolet irradiation (UV) may also induce skin tumors. However, no report exists regarding the effect of topical active vitamin D3, tacrolimus, or corticosteroids on UV-irradiation-induced skin tumors. 1.2. Objective
    Using ultraviolet B (UVB)-induced papilloma model, we compared the effect of active vitamin D3, tacrolimus, and corticosteroid ointments on the skin papilloma formation.
    Methods: Various corticosteroids (betamethasionevalelate, betamethasonebutyrate propionate), active vitamin D3 (tacalcitol, carcipotriol, maxacalcitol), tacrolimus, or white petrolatum ointments were applied twice a week on the mice skin following UVB-irradiation (200mJ/cm2). The number of UVB-induced skin papillomas was counted at the indicated time.
    Results: Papillomas were induced at 12 weeks on the UVB-irradiated mouse skin. The number of papilloma was significantly decreased on active vitamin D3 ointment-treated mice skin. However, the anti-tumor effect was not observed on corticosteroids or tacrolimus ointment-treated skin.
    Conclusion: Active vitamin D3 ointments show potent anti-tumor effect on UVB-treated mouse skin. The active vitamin D3ointments might decrease the risk of UVB-induced skin tumors under phototherapy.
    Oscar Daniel Salvioni, JosééPereira, Marco González Sander, and Celeste Vega Gómez*
    Leishmaniasis is one of the most important vector-borne human diseases. Different parasite species are associated with the various forms of the disease. In Paraguay, visceral leishmaniasis is caused by L. infantum, whereas tegumentary leishmaniasis is due mainly to L. braziliensis. Recently, two cases of patients with atypical cutaneous lesions have been described in which the causative agent was determined to be L. infantum. Based on these findings, we aimed to determine the leishmania species of all cutaneous and mucosal biopsy lesions submitted to our research center during 2016 using real-time PCR. We found that 20% of all tegumentary leishmaniasis were due to L. infantum and most of these patients presented with atypical cutaneous lesions and no visceral involvement.
    Case Report
    Camille Picard*, Cecile Morice, Anne Moreau, Anne Dompmartin, Andrea Stefan, and Laurence Verneuil
    Phytophotodermatitis are phototoxic cutaneous reactions that are linked to a photosensitising plant in conjunction with exposure to the sun. They most often take the form of a rash consisting of vesicles or bullae, sometimes very marked, and residual hyperpigmentation.
    We report four cases of phytophotodermatitis in children with varied clinical presentations. The plant thought responsible was identified in one of the cases – Heracleumgiganteum (Giant Hogweed), which is rich in photosensitisingfurocoumarins.
    Diagnosis of these phytophotosensitisations can be difficult because it is easy to confuse with herpes infection, bullous impetigo, cutaneous allergies and even child abuse. It is when the patient or the parents are questioned on contact with certain plants in sunny conditions, often not spontaneously reported, that the diagnosis can be made. Evolution is generally positive and spontaneous after brief local corticotherapy.
    Clinical Image
    Elizabeth Donner, Israel D. Andrews, Stephanie Ryan, and Jennifer J. Schoch*
    An 8-week old male born at 36 weeks gestation presented to clinic with a progressive rash. At birth, he was noted to have an erythematous atrophic macule on the upper lip.
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