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  • ISSN: 2334-1815
    Current Issue
    Volume 5, Issue 2
    Research Article
    Bystrov VS*, Bdikin IK and Silibin MV
    Recent advantages in experimental and computational studies of new composite nanomaterials based on polymer ferroelectrics and graphene/graphene oxide are presented. Main results of the computational molecular modeling of various nanostructures and the piezoelectric properties of the composites from polyvinylidene fluoride (PVDF)/poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) films and graphene/graphene oxide (G/GO) were reviewed and analysed in comparison with the experimental data at the nanoscale, particularly with atomic force and piezo-response force microscopy (AFM/PFM) data. The performed computational molecular modeling of the graphene/graphene oxide (G/GO) and PVDF ferroelectric polymer composite nanostructures, were studied by the different methods using HyperChem tool: molecular mechanics (MM) methods (BIO CHARM), quantum mechanical (QM) calculations based on density functional theory and semi-empirical PM3 method. Experimentally the switching behavior, piezoelectric response, dielectric permittivity and mechanical properties of the films were investigated and found to depend on the presence of G/GO concentration. Experimental results qualitatively correlate with those obtained in the calculations. Particularly, computed data of the piezoelectric coefficients d33 for developed PVDF-G/GO models are in line with observed experimental behavior with concentration changes of GO components. The results obtained in the reviewed and analysed present study provide important insights into our understanding of the mechanisms of piezoelectricity in such new nanocomposites, give us new prospective for further creation, development and applications of novel ferroelectric polymer–graphene/graphene oxide nanocomposites as multifunctional nanomaterials.
    Melnikova NB*, Kochetkov EN, Gubskay VP, Fasleeva GM, Gilmutdinova AA, Islamova LN, Nizameev IR, Kadirov MK, and Nuretdinov IA
    The interaction between bis-methanofullerene tris-phosphonic acid (FTPA) and cytochrome c (cyt c) by using Langmuir-Shaeffer monolayers technique combined with AFM was studied. The FTPA molecules form stable Langmuir monolayers on the subphase of aqueous cyt c solution in contrast to the surface film of an island type under water. The values of limiting area A0 of FTPA in monolayers depend on cyt c concentration in the subphase and are increased from 0,5 nm2 (Ccyt c=1 mg∙l-1) up to 2,6 nm2 (Ccyt c=10 mg∙l-1). The compressibility modulus study reveals that the immobilization of cyt c in FTPA monolayers may change the surface film fluidization. AFM photos of transferring FTPA monolayers suggest the immobilization of cyt c into FTPA. It has been shown that cyt c into FTPA film can be able to act as an oxidant in the reaction with nitric oxide.
    Perspective
    Martin Bidney*
    The goal of the research presented here was twofold: (1) to establish the nature of a recurrent pattern in the literary epiphanies (moments, intense, mysterious, and rich in implication) in the shorter works of the celebrated fictionist Eudora Welty (1909-2001) and (2) to indicate the apparent implications of these moments for a theoretical and practical understanding of what I call manic agitation, one of the “mixed states” (Jamison 1993) that often occur in manic-depressive or bipolar syndrome. The methodology in pursuing the first goal was defined in such a way as to make it independent of the second one: the pattern shaping the visual content of the intense literary moments was determined first and the psychological implications explored later. But these implications were not hard to find. Indeed, Welty’s epiphanic pattern proved to be an ideal metaphor to clarify a troubling jump that blended the attraction and peril of the “mixed state” Jamison depicts. The Welty pattern was one of quantum leaps, each a sudden accession of a new level of awareness joyful and menacing, exhilarating and potentially fatal.
    Short Communication
    Vanita S. Bhat, Soma Patnaik, and Basavaraj Madhusudhan*
    Nanobiotechnology has prompted new and improved materials for biomedical applications with particular emphasis in gene and drug therapy, imaging and diagnostics. Most recently, drug delivery and targeting of molecular therapeutics for cancer is gaining momentum to overcome existing drawbacks such as toxicity and side-effects. 'Proteomics' and 'genomics' have emerged as challenging areas of nanomedicine. This short communication tries to summarize a portion of most advanced developments in immunotherapy application using noble metals like gold nanoparticles as carriers especially for breast cancer therapy.
    Review Article
    Eepsita Priyadarshini and Kamla Rawat*
    Quantum dots (QDs) represent a group of semiconductor nanomaterials with fascinating optical and fluorescence properties. Their unique optical and electronic properties have resulted in innumerable modes of synthesis, and subsequently, wide-ranging applications. However, disadvantage of QDs is its aqueous insolubility that limits its application when it comes to their use in biomedicines, like in vivo and in vitro imaging and sensing. Therefore, ligand exchange reactions and surface coatings are employed to circumvent this problem. Additionally, these protocols minimize the risk of toxicity normally associated with QDs. Furthermore, the use of QDs in bioimaging holds significant advantages over the conventionally used fluorescent dyes with regard to photostability, fluorescence lifetime and tunable emission behavior. Additionally, there has been significant advancement in the use of biorecognition of molecules that are conjugated to QDs for enhancing specificity. In this review, we have analyzed and discussed the advancements and the current state-of-art of QDs in biology and medicine.
  • Current Issue Highlights
  • Principles and applications of dielectrophoresis (DEP) of biomolecules, suspended in aqueous medium, are reviewed.
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    In this work, microporous TiO2 photocatalyst (IL-TiO2) with high photocatalytic performance was prepared via a sol-gel method using the ionic solvent
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