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  • ISSN: 2334-1815
    Early Online
    Volume 5, Issue 3
    Research Article
    Dai Hai Nguyen*
    In this study, superparamagnetic Fe3­O4 nanoparticles were surface coated with heparin-Pluronic (HP) for Doxorubicin (DOX) delivery. In detail, Fe3O4 nanoparticles were prepared and then coated with HP (Fe3O4@HP) conjugate by co-precipitation method. Furthermore, the formation of Fe3O4@HP was demonstrated by fourier transform infrared (FT-IR) and Powder X-ray diffraction (XRD). The superparamagnetic property of Fe3O4@HP was also showed by hysteresis loop analysis, the saturation magnetization reached 24.92 emu g-1. In addition, sizes and morphologies of Fe3O4 and Fe3O4@HP nanoparticles were spherical shape with average diameter of 19 nm as compared with Fe3O4 nanoparticles (12 nm), were determined by transmission electron microscopy (TEM). Especially, DOX was effectively loaded into the coated magnetic nanoparticles, 66.9% ± 2.7% for drug loading efficiency and slowly released up to 120 h. These results suggest that the potential application of Fe3O4@HP nanoparticles in the development of stable drug delivery system for cancer therapy.
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