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  • ISSN: 2578-3580
    Early Online
    Volume 4, Issue 1
    Research Article
    Lebedev SV*, Karasev AV, Viktorov IV, Chekhonin VP, Savchenko EA, Grinenko NF, Lazarenko IP, and Volgina NE
    Cellular preparations (CP) of embryonic nerve tissue previously derived form 9-day-old rat embryos (rENT) and human olfactory neural stem cells. (hoNSC) were used for single injection into the brain or under the skin of rat pups three days after inducing various-severity perinatal injury of the CNS (CNS PI). Cultivated rat fibroblasts (rF), i. e. non-progenitor cells, were implanted as cellular control. We used the animal models of PIs most adequate to clinical manifestations of severe cerebral palsy - a model of perinatal hypoxic ischaemic brain damage (PHIBD) by the Rice and a model of minimal cerebral dysfunctions syndrome – neonatal anoxia (NA) according to the technique suggested by Speiser. All the mentioned cell types labelled with vital dye CFDA-SE preserved their vitality for not less than 28 days following intracerebral or subcutaneous administration.
    Two-month-long weekly monitoring of the motor activity (the "Rotarod" tests, “hanging”) and cognitive functions (Passive avoidance, Y-maze) showed that implantation of cell preparations of rat fibroblasts (rFCP) (cellular control) exerted no appreciable effect on the functional state of the rat pups. In contrast, implantation of hoNSC CP and rENT CP into the brain and under the skin resulted in considerable restoration of the impaired functions both in rats with PHIBD and those with NA. Subcutaneous implantation turned out to be not less efficient than implantation of cells directly into the brain. No differences in efficacy of implantation of xenogenic hoNSC and allogenic rENT cells were observed. The findings obtained in the present study suggest a possibility of non-specific neuroprotective effect of cell preparations implanted intracerebrally or subcutaneously to rat pups with perinatal lesions of the brain.
    Review Article
    Jordan Kelly*
    Stem cell research may revolutionise our understanding of how we develop and function and offer potential treatments for debilitating diseases including Parkinson’s disease, spinal cord injury and Huntington’s disease. However, Human Embryonic Stem Cell (HESC) research has been surrounded by both ethical and political controversy. The isolation of these pluripotent stem cells has caused arguments regarding the beginning of human personhood. Along with these ethical issues, several practical issues arise in HESC research including immunogenicity issues after transplantation. Legal restrictions in various countries have also hindered the progress of HESC research, creating a difficult environment for advancement in the field. Induced Pluripotent Stem Cells (IPSCs) have offered a potential replacement to HESC research by avoiding the ethical and practical issues associated with HESC. However more research and trials are required to gain a better understanding of their therapeutic mechanism of action and to assess the potential risks and side effects associated with both HESC and IPSC transplants. Trinity College Dublin.
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