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  • ISSN: 2333-6641
    Early Online
    Volume 1, Issue 2
    Review Article
    Pooja Prasad1*, Rajiv Desai1, Shivani Bansal1, Pankaj Shirsat1 and Praveen Raipure2
    Human stem cells have a major effect in the development of human bodies. Acting as an in vitro model, human stem cells have a great value in the study of the mechanism of individual development and in the cell replacement and regeneration treatments and gene therapy of tissue deficiency diseases.
    This article gives a brief overview on recent advances in the field of stem cell research and its advancement in enhancing the field of tissue engineering especially pertaining to advanced dental treatment modalities; encompassing tooth, bone, cartilage, skeletal tissue and other variants of tissue engineering.
    Baoxue Yang*
    Abstract: Urea transporter (UT) proteins, including isoforms of UT-A in kidney tubule epithelia and UT-B in vasa recta endothelia and erythrocytes, play an important role in the urine concentration mechanism by mediated an intra renal urea recycling, suggesting that functional inhibition of these proteins could have therapeutic use as a novel class of diuretic. Recently several classes of UT inhibitors have been identified and found to functionally inhibit UTs. A class of thienoquinolins, which specifically inhibit both UT-A and UT-B, exhibit diuretic activity. It is predicated that UT inhibitors have potential clinical applications as sodium-sparing diuretics in edema from different etiologies, such as congestive heart failure and cirrhosis.
    Sethi J1* and Singh J2
    Abstract: Complementary and alternative medicine involves the use of herbs and medicinal plants as an alternative to mainstream western medical treatment. A large number of Indian medicinal plants have been reported to possess immunostimulant activity and thus can serve as potential source of drug in various immunocompomised states including AIDS, cancer and for treatment of various chronic infections. This review describes role of plant derived Immunostimulants in health care.
    Joana Coimbra, Carolina Mota, Sofia Santos, Pedro Viana Baptista, and Alexandra R. Fernandes*
    Abstract: Transition-metal complexes have shown significant anti-tumour potential and have advanced towards clinical trials. However, tumour cells often develop resistance to chemotherapeutics, which couple to the inherent compound's' toxicity and solubility hampers their translation to the clinics. Therefore, besides the tremendous efforts to synthesise and characterise novel compounds, it is essential to create new drug delivery systems that circumvent these problems, allowing specific and selective delivery of drugs to tumour cells, thus decreasing the required dose and reducing side effects to the healthy tissue. Nano biotechnoloy has been providing for innovative solutions to address this challenge, via the smart design of nano formulations suitable for targeted delivery to the tumour microenvironment. In this review, we discuss recent nano systems combined with medicinal chemistry in cancer therapeutics, focusing on the clinical translation of such systems.
    Research Article
    Eric Lattmann1*, Simon Dunn1, Carl H. Schwalbe1, Wanchai Airarat2, Andrew J. Shortt2 and Jintana Sattayasai2
    Abstract: The 3-brominated pyrroldione 1a served as starting material for the preparation of a series of substituted N-methyl 3-amino-pyrrol-2,5-diones, using a Cu catalysed substitution reaction. Initially the newly synthesised compounds were tested at a high dose for CNS depressant activity. When the activity was found significantly different from the control in the rota rod test and the wire mash grasping test at a high dose the active compounds were evaluated further at a low dose in anxiolytic assays. The pyrroldione 2p showed a good anxiolytic activity at low doses of 1/0.1 mg/kg in the light/dark box and the elevated plus-maze assay. The n-hexyl-amino pyrrol 2e served as lead structure for further structure optimisation. Based on 5-alkoxy 3,4-dichloro-2(5H) furanones 3a and 3b, a second series of bis-substituted pyrroldiones was prepared under Cu catalysis and the pyrroldione 4f occurred the most potent anxiolytic activity.
    Research Article
    Abdrrahman Shemsu Surur*, K.K Rajasekhar, Kommana Balaram Kumar and Yenus Tadesse Mekonnen
    Introduction: Cathepsin K is being targeted for the treatment of various human disease including osteoporosis and cancer. In the present study, a compound, which contains a 2-cyanopyrimidine scaffold with optimal substituents that can interact with S2 and S3 subsites of cathepsin K, was derivatized.
    Objective: To determine the in silico binding affinity, the toxicity and physicochemical properties of 1-[2-(3-biphenyl)-4-methylvaleryl)] amino-3-(2pyridylsulfonyl) amino-2-propanone and its derivatives.
    Methods: UCSF chimera was used for macromolecule preparation and Autodock Vina was used for calculating binding affinities. PyMOL and UCSF Chimera were used to analyze the postdock binding interactions of the derivatives. Osiris property explorer was used to predict the toxicity and certain selected physicochemical properties of the derivatives.
    Results: The substitution of the phenoxy moiety with lipophilic substituents was found to increase the binding affinity, unlike substitutions made on the cyanopyrimidine moiety. The derivatives were found to have high binding affinity and were non-toxic, but showed low drug likeness and drug scores.
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