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  • ISSN: 2333-6641
    Volume 5, Issue 6
    Review Article
    Ayse Ulgey*, Aynur Mustafayeva, and Buket Kapcak
    Current increase of invasive and noninvasive clinical procedures creates great demand for sedation. This sedation may also provide analgesia, anxiolysis, and hypnosis. Protection of respiratory and cardiovascular system is very crucial in anesthesia and intensive care procedures. Thus appropriately given sedation may reduce the duration of surgical procedures, create excellent pain management, improve the quality of technique and increase patient comfort. Moreover, selection, dosing, combination and administration of proper anesthetic medications are important for appropriate sedation and anesthesia.
    Current papers show that Dexmedetomidine is widely and safely used anesthetic medication in pediatric and adult population. It may be administered for sedation, analgesia, general and regional anesthesia alone or with another drug combination. Dexmedetomidine provides sedation with no respiratory depression that makes an advantage in clinical use. Dexmedetomidine is also introduced as an organ protective anesthetic medication.
    High bioavailability of sublingual dexmedetomidine which is about 84% increases the importance of it in pediatric sedation settings. Excretion ways are mostly urine (95%) and feces (4%).
    Emergency medicine, surgery, cardiology (PCC), radiology (MRI and CT-scan, EEG), Intensive Care unit are the fields where dexmedetomidine extensively used.
    Case Report
    Rohini M. Surve*, Dwarakanath Srinivas, Ganne S. Umamaheswara Rao, Sonia Bansal, Kadarapura N. Gopalkrishna, and Venkataramaiah Sudhir
    Pantothenate Kinase – associated neurodegeneration (PKAN) is a rare autosomal recessive disorder. PKAN presents with severe incapacitating dystonias, rigidity and cognitive impairment usually in early childhood. The initial treatment of patients suffering from PKAN constitutes medical line of management, but for those patients who are refractory to medical management surgical treatment is an option. Perioperative anaesthetic management is a challenge in view of generalized dystonias, restricted airway access due to head frame, need for an awake and co-operative patient, and to provide ideal conditions for intraoperative microelectrode recordings (MERs) under anesthesia. All these factors demand an appropriate anesthetic technique. It further becomes challenging if the surgical procedure is performed on children, since they require general anaesthesia which in turn can interfere with the interpretation of MERs and clinical assessment. We report two cases of PKAN who underwent surgical treatment using dexmedetomidine (alpha agonist) as the principal anesthetic agent.
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