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  • ISSN: 2578-3351
    Current Issue
    Volume 1, Issue 1
    Short Communication
    Mai Aly, Reda Z. Mahfouz*, and Iman Eltonsi
    Hematogones (HGs, normal B-lymphocyte precursors) were first described in 1937 by Peter Vogel as "lymphoid-appearing cells" in bone marrow aspirates from children. HGs in Latin mean "blood-maker". The function and significance of these cells remained unclear till the 1970s when flow cytometry was used to identify them. HGs may be particularly prominent in the regeneration phase following chemo-therapy or bone marrow transplantation. Moreover, Increased HGs may cause misinterpreted because they share morphologic features with neoplastic lymphoblasts. In this review, we tried to focus on current morphologic and immunophenotypical characterization of HGs and their clinical significance as diagnostic and prognostic tool in predicting patient outcomes. We have examined several studies to evaluate risk ratio of HGs level at certain cut off limit which has been proposed in majority of studies. Out of 21 studies which included 1150 patients with different hematological malignancies and bone marrow failure syndromes and 590 post transplantation patients. We report how HGs detection would help in diagnosis and predict outcome in bone marrow transplantation patients.
    Case Report
    Elena M. Brach Del Prever*, Tiziana Robba, Alessandra Linari, Armanda De Marchi, Raimondo Piana, Michele Boffano, Alessandro Comandone, and Alessandro Masse
    High grade chondrosarcoma (CS) is a surgical disease despite its aggressive behavior of recurring locally and spreading to the lungs; conventional chemo- and radiotherapy are ineffective. Pelvis is frequently involved: calcified mass invading the pelvis and bone lytic area with amorphous snow flake calcification are typical. To obtain adequate margins, surgery is highly demanding with severe residual disability. Some preliminary in vitro studies showed that Nitrogen-containing Bi Phosphonates (N-BPs) may play a role in the treatment of CS; in vivo only sporadic cases are reported. We report on a 83-year-old man patient affected by high grade CS of the left pelvis, characterized by radiographic abundant preminent unusual sclerotic bone, and the typical large calcified mass spreading into the pelvis. The tumour developed at least 10 years before, when a typical sclerotic and lytic lesion at the left pelvis, hypercaptant at whole body bone scintigraphy, was documented and misdiagnosed. During these last 10 years the patient was treated with N-BPs weekly for fragility vertebral fractures and primary hyperparathyroidism. We hypothesize that N-BPs inhibited the bone resorption, induced bone sclerosing and controlled pain for many years. This case suggests that N-BPs may play a role in controlling the development of CS and pain, confirming the in vitro results.
    Caitlin O'Neill*, Imran Siddiqi, Stephen Gruber, Kevin McDonnell, Sharon Moayeri and Casey O'Connell
    Familial platelet disorder with propensity for myeloid malignancy (FPD/AML), an autosomal dominant disorder associated with mutations in the RUNX1 gene, is characterized by mild to moderate thrombocytopenia, abnormal platelet function, and an increased risk of developing myeloid malignancy. We describe a pedigree with a novel RUNX1 mutation in which the prob and presented with mild thrombocytopenia. She had undetectable IgA levels (<5 mg/dL) as did her mother who had died from myelodysplastic syndrome. A germline heterozygous nonsense mutation in exon 7 of the RUNX1 gene (c.667G>T (pE223X)) was detected on peripheral blood sampling. Her maternal half-brother with a history of celiac disease tested positive for the same mutation. The patient was undergoing in vitro fertilization at the time of diagnosis and a wild-type RUNX1 embryo was selected for implantation with subsequent delivery of a healthy baby. We contribute a unique finding of IgA deficiency to the clinical phenotype of FPD/AML. This is also the first report of embryo selection being used to prevent inheritance of an autosomal dominant RUNX1 mutation.
    Case Series
    Gillian M. Powderly and Ryan P. Moenster*
    There is limited evidence supporting the use of ceftaroline to treat osteomyelitis. We report a series of 5 patients who received ≥ 7 days of ceftaroline therapy for documented cases of osteomyelitis. One of 5 patients did not require additional antibiotics or surgical intervention 6 months after completion of therapy.
    Review Article
    Stahl Ido*, Peskin Bezalel, Falah Mazen, Ginesin Eyal, Sachs Ofer, and Nierenberg Gabriel
    The meniscus has an important biomechanical role in the normal function of the knee including load bearing, shock absorption joint stability and efficient synovial fluid dispersion. Tears of the meniscus are one of the common sport injuries. The outcome of meniscectomy causes early development of degenerative changes.The repair prevalence of meniscal tear, in order to preserve meniscal tissue and knee function, gradually increases. The type of tear, shape, location as well as general factors such as age and associated pathology have a critical effect on the ability to heal after suture of the tear.
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