Recent Articles
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February 29, 2024 Research ArticleAbstract A potent stimulation of fibroblast collagen production is one of the crucial pleotropic effects of transforming growth factor ? (TGF-?) and has been considered to play a crucial role in the pathogenesis of fibrotic diseases including Systemic Scleros.....
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February 29, 2024 Review ArticleAbstract The examination of the prostate biopsy procedure is essential in the optimization of the diagnostic pathway of such a prevalent affliction as prostate cancer among men worldwide. With the core needle biopsy being the standard of care for the diagnosi.....
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October 31, 2023 Review ArticleAbstract Aquaporins (AQPs) are small, integral proteins facilitating water transport across plasma cell membranes in reaction to osmotic gradients. This family has thirteen unique members (AQP0-12), which can also transport glycerol, urea, gases, and other sa.....
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July 31, 2023 Research ArticleAbstract Aim: Radiotherapy is an important treatment modality against breast and thoracic cancer, bringing significant improvement in tumor control and survival. Nevertheless, it also results in variable degrees of cardiac exposure to ionizing radiation. Resu.....
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May 21, 2023 Case ReportAbstract Malignant tumor complicated with hemophagocytic lymphohistiocytosis (HLH) is a rare disease that seriously endangers life and health in the oncology department. The treatment and diagnosis of and fever of unknown origin. Due to the rapid aggravati.....
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April 27, 2023 Review ArticleAbstract Protein tyrosine kinases (PTKs) phosphorylate select tyrosine residues on target proteins and activate various signaling pathways essential for regulating diverse physiological and pathological processes. Aberrant activation of PTKs causes abnormal c.....
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March 29, 2023 Review ArticleAbstract The tumor suppressor gene p53 is a key regulator of cell growth and apoptosis, and its loss of function due to mutations or other mechanisms is frequently observed in cancer. Recent research has elucidated the complex role of p53 in cancer developmen.....
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April 30, 2014 Review ArticleAbstract In recent decades the age-specific mortalities of lung cancer in China have been increased to 9 times in men and women and it become one of the most important public health issues. The high prevalence of smoking in men and more than 70% of nonsmok.....
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April 24, 2014 Short Communication
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March 15, 2014 Review ArticleAbstract In China, Small Cell Lung Cancer (SCLC) accounts for over 15% of lung cancers. Until now, the morbidity of SCLC has been increasing due to the ineffective smoking cession in China. Following the Chinese Guidelines of SCLC, the treatment of SCLC in .....
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April 07, 2014 Research ArticleAbstract Background: Postoperative acute exacerbation of Idiopathic Interstitial Pneumonia (IIP) is known to be a catastrophic complication in the surgical treatment for primary lung cancer with concomitant IIP. Investigation of clinical factors associated w.....
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March 20, 2014 Research ArticleAbstract Objectives: Endocytoscopy is a new endoscopic imaging device for in vivo visualizing cellular structures. The aim of this study was to observe lung cancer cells using an endocytoscopy and compare them with the microscopic findings. Methods: Between.....
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March 20, 2014 Review ArticleAbstract Malignant Pleural Mesothelioma (MPM) is a highly lethal and refractory malignancy that is caused by asbestos exposure. Surgical resection, radiotherapy, and other local treatments are of limited efficacy. Therefore, systemic chemotherapy plays an .....
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March 17, 2014 Research ArticleAbstract A Large Cell Neuroendocrine Carcinoma (LCNEC) of the lung is highly malignant. Reduced or abnormal expression of adhesion molecules, such as E-cadherin and b-catenin, on the cell membrane is associated with the aggressiveness of its tumor cells, w.....
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March 15, 2014 Case ReportAbstract A 75-year-old man complained of pain and swelling of the right shoulder for 2 months. Plain chest radiography revealed a mass in the right upper lung field and dissolution of several ribs. Bronchoscopic brush cytology showed class V squamous cell .....
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March 15, 2014 Research ArticleAbstract Despite recent advances in surgical and multimodality treatments, lung cancer is still the leading cause of death due to malignant disease worldwide. In Japan, the number of surgical procedures for lung cancer has been steadily increasing (31,303 .....
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March 15, 2014 Research ArticleAbstract Conventionally, it has been believed that oncogenesis accompanying chromosomal translocations such as BCR-Abl in CML is limited to particular tumors such as hematologic diseases, etc. However, the presence of the EML4-ALK fusion gene in lung cancer.....
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March 15, 2014 Review ArticleAbstract The advent of molecular targeted drugs and effective second-line treatment for inoperable, advanced, Non-Small Cell Lung Cancer (NSCLC) has rapidly improved treatment outcomes. Conventional first-line chemotherapy regimens included all NSCLC, with.....
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March 15, 2014 Case ReportAbstract We herein present three autopsy cases of unusual malignant mesotheliomas with peculiar histological features. Case 1: The patient was a 69-year-old female. The tumor encased the entire left lung, and metastasized to multiple organs. Histologicall.....
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March 15, 2014 Short Communication
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April 07, 2014 Editorial
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April 07, 2014 Perspective
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March 17, 2014 Short Communication
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March 15, 2014 Review ArticleAbstract Obesity increases the incidence of many types of cancers, and as the incidence of obesity continues to rise, the frequency of obesity-associated cancers will likely increase. While obesity increases postmenopausal breast, endometrial, pancreatic, c.....
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March 15, 2014 Case ReportAbstract Metastasis to the breast represents 0.4-1.3% of all breast malignancies. In those rare instances, the primary site is usually leukemia, lymphoma, or melanoma. Lung cancer, mostly adenocarcinoma, has been reported to be associated with metastasis to.....
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March 17, 2014 Mini ReviewAbstract Deregulation of Rho GTPase expression and activity levels is found in a number of cancers, including breast cancers. Aberrant Rho GTPase signaling promotes tumorigenic behaviors in a cell-autonomous manner. The development of conditional knockout a.....
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March 15, 2014 Review ArticleAbstract High mammographic density confers a significantly increased risk of breast cancer. As it is relatively common in the normal population the risk of cancer attributable to increased mammographic density could potentially account for an important per.....
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January 19, 2014 Review ArticleAbstract Breast cancer is the commonest malignancy among women in countries within the Eastern Mediterranean Regions (EMR). In Iraq, it comprises approximately one third of the registered female cancers. Other features that justify increasing efforts for br.....
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January 19, 2014 Editorial
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July 11, 2019 Research ArticleAbstract This study was conducted to investigate the potential therapeutic effect of Melatonin (Mel) and/or mesenchymal stem cells (MSCs) on diethylnitrosamine (DEN)- induced rat model of HCC. Female mature rats were divided into 5 groups (n = 10/group): no.....
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May 25, 2018 Research ArticleAbstract Objective: To investigate the expression of COX-2 gene in patients suffering from esophageal squamous cell carcinoma Study design: Descriptive Place and duration of study: Institute of Basic Medical Sciences, Khyber Medical University Patients an.....
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January 21, 2017 Research ArticleAbstract Background: The ability to identify patients that have disease progression soon after surgical resection could guide treatment as well as aid in the development of novel targeted therapies. This study correlates gene expression and overall survival .....
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October 17, 2016 Review ArticleAbstract Epigenetic abnormalities are now realized as important as genetic alterations in contributing to the initiation and progression of cancer. Recent advancements in the cancer epigenetics field have identified extensive alterations of the epigenetic n.....
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October 23, 2015 Short CommunicationAbstract Background: There is recent interest in the use of antiandrogen therapy to treat metastatic androgen receptor positive (AR+) ‘triple negative’ metastatic breast cancer. Since AR testing is not routinely done, we conducted a pilot study to deter.....
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October 12, 2015 Case ReportAbstract Ecthyma gangrenosum is the cutaneous manifestation of bacteremia traditionally associated with Pseudomonas Aeruginosa bacteremia. It classically presents as gunmetal grey bullae with a pink macular margin. To our knowledge, no case reports exist d.....
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October 12, 2015 Research ArticleAbstract Targeting of the tumor vasculature has evolved into an integral part of existing standard anti-cancer therapies. However, recent pre-clinical and clinical studies have shown that the efficacy of these treatments is often temporary and frequently fo.....
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October 12, 2015 Case ReportAbstract Ecthyma gangrenosum is the cutaneous manifestation of bacteremia traditionally associated with Pseudomonas Aeruginosa bacteremia. It classically presents as gunmetal grey bullae with a pink macular margin. To our knowledge, no case reports exist d.....