AbstractDrug-resistance remains one of the main challenges for cancer chemotherapy. The failure of due to drug-resistant tumors accounts for much of the relapse and cancer mortality seen today. What makes it challenging to address this issue is that tumo.....
AbstractThe unlimited growth potential of tumors depends on telomere maintenance and typically depends on telomerase, an RNA-dependent DNA polymerase, which reverse transcribes the telomerase RNA template, telomere repeats at the ends of chromosomes. Stu.....
AbstractNow an aging society is coming in the world. In the United
States, it is estimated that the percentage of people 65 years
and older will increase from 13% to more than 20% of the total
population by 2030. As a result, the elderly cancer patient.....
AbstractLeptomeningeal carcinomatosis is most commonly seen
in breast carcinoma, lung carcinoma, and melanoma. The
identification of malignant cells in the CSF constitutes the gold
standard for diagnosis. However, the sensitivity of a single CSF
anal.....
AbstractMuscle-invasive bladder cancer (MIBC) is a lethal disease
for which cytotoxic, platinum-based chemotherapy remains the
standard of care. Recent insights into the genomic landscape of
MIBC reveal a highly heterogeneous disease. As a result, targ.....
AbstractIn the past, cancer development was generally considered to
be a disease that is caused by genetic alterations (e.g., mutations,
chromosomal abnormalities) in tumor-suppressor genes and/or
oncogenes. However, it has become increasingly apparent.....
AbstractSigma receptors are a distinct class of receptors that are found
in many tumors and normal tissues and have been associated
with many cellular and organ processes, including motor
function, endocrine function, proliferation, immunoregulation
.....
AbstractAdvances in genomic sequencing technologies and computational and analytical methods are now allowing us to characterize at single base-pair resolution of cancer genomes and amass an unprecedented amount of information. However, the gap between ge.....
AbstractATM, ATR and DNA-PK are critical for DNA damage response (DDR) and sequential repair, leading to genomic stability. In this study, we found the expression of these proteins is markedly induced by PMA during THP1 differentiation without the change .....
AbstractUS biomedical research including epidemiology research
has been criticized that a majority of the research findings are
not translational. That is, researches have limited direct impact
on improving patient care and public health [1]. In a move.....
AbstractThe findings that the retinoblastoma tumor suppressor gene
product (pRB) controls gene expression by physically interacting
with several epigenetic regulators reveals another potential
form of the RB functions in global regulation of the epigen.....
AbstractBRCA1-associated ATM activator-1 (BRAT1) was identified by our group as a DNA damage response (DDR) protein, which can bind with many DDR proteins and regulates their functions after DNA damage. However, previous study has also implicated BRAT1 as.....