AbstractPersonalized medicine, the selection of both patient and treatment, is based on a multitude of ‘in-vitro’ pathology and molecular biology analyses that are almost exclusively performed on sliced and homogenized diseased tissues. Appropriate te.....
AbstractGenetic and epigenetic alterations have important implications inhuman cancer. Genetic aberrations are associated with wide spread variations in deregulation of cellular functions that lead to cancer. However, there has been clear evidence that ep.....
AbstractIntroduction: Breast cancer has remained the most commonly diagnosed disease among women globally. Despite the advancement in biomedical sciences leading to improve survival outcomes, some patients endure longer wait periods prior to initiation of.....
AbstractEcthyma gangrenosum is the cutaneous manifestation of bacteremia traditionally associated with Pseudomonas Aeruginosa bacteremia. It classically presents as gunmetal grey bullae with a pink macular margin. To our knowledge, no case reports exist deta.....
AbstractTargeting of the tumor vasculature has evolved into an integral part of existing standard anti-cancer therapies. However, recent pre-clinical and clinical studies have shown that the efficacy of these treatments is often temporary and frequently fo.....
AbstractPurpose: Remarkable differences in breast cancer incidence in the three main ethnic groups in Singapore have been described, we report the survival differences.
Methods: Using the Singapore national breast cancer registry, and a local hospital regi.....
AbstractBackground: Breast cancer is the main cause of death by cancer in Mexican women of age 25 or older. This disease has steadily increased amongst young women. They usually present an aggressive and advanced breast cancer. Methods: Data on women diag.....
AbstractThe Patient Protection and Affordable Care Act (PPACA) put into federal law numerous opportunities for cancer research and cancer epidemiology. The legislation created the Patient-Centered Outcomes Research Institute (PCORI) and established the ty.....
AbstractCancer is intricately linked to our evolutionary history. The origin and progression of cancer can hence be better understood when viewed from an evolutionary perspective. In this review, we portray the fundamental fact that within the complex eco.....
AbstractChromosomal translocation of the EWSR1 gene with the members of ETS gene family of transcription factors results in the generation of a chimeric transcription factor that underlies the hallmark signature of Ewing sarcoma family of tumors (EFTs). Th.....
AbstractWe investigated the relation between MDR-1 gene single-nucleotide polymorphisms (SNPs) and treatment outcome in chronic myeloid leukemia (CML) patients. Two groups of patients were included: group 1 (resistant group) consists of 29 CML patients and.....
AbstractHemophagocytic Lymphohistiocytosis (HLH) is a clinical syndrome that develops due to the unregulated activation of the inflammatory system and is considered when a patient presents with a constellation of symptoms and objective findings consisting .....
Abstractfections with similarities to exogenous retroviruses and make up 8% of the entire
human genome. HERVs are found to play a role in carcinogenesis. We sought to
analyze 37HERVs in relation to 16 types of cancers using phylogenetic analysis. HERVs
.....
AbstractFreezing of eggs or ovarian tissue to preserve fertility for cancer patients
has been studied since 1994 with Gosden’s original paper in sheep, and before that in smaller mammals for decades prior. Clinically, this tactic has enjoyed great succ.....
AbstractColorectal cancer (CRC) which affects over one million individuals annually [1] has recently seen an increased interest in identifying biomarkers and new treatment strategies. This has resulted in a significant rise in the median overall survival .....
AbstractColon cancer is a common malignancy associated with significant mortality. Colon
carcinogenesis generally occurs in a slow and stepwise process of accumulating mutations
under the influence of genetic and environmental factors, the so-called aden.....
AbstractCripto-1 (TDGF-1) is a cell surface glycosylphosphatidylinositol-linked glycoprotein which functions as an obligatory co-receptor for transforming growth factor-? (TGF-?) family members. Cripto-1 is essential for early embryonic development and mai.....
AbstractMustard gas has been used as a chemical weapon since 1917 during World War I. Since then, many reports have shown that survivors of attacks and those who make mustard gas exhibit a higher incidence of cancer than the normal population. We have rec.....