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  • ISSN: 2379-061X
    Early Online
    Volume 6, Issue 1
    Editorial
    Jabbar KHAN*
    Thyroid is a gland at the front of neck beneath larynx and consists of two lobes which are connected by a piece of tissue, the isthmus. The thyroid makes two important hormones; thyroid hormone, which affects heart rate, blood pressure, body temperature, and weight, and calcitonin, which keeps the healthy level of calcium in the body.
    Research Article
    Burra Gunasekhar* and Subash Chandra Malik
    Ribosomal binding factor A (RbfA) and YjeQ, ribosome small subunit-dependent GTPase A (RsgA) are two important ribosome assembly factors among many factors involved in maturation of 30S ribosomal subunit. They exhibit a functional interplay, both at the genetic and molecular levels during the maturation of 30S ribosomal subunit. Recently, an abnormal ribosome profile with low ratios of 70S ribosomes to the 50S and 30S subunits was observed in ?YjeQ cells as compared to wild type. This results in the death of ?YjeQ cells due to improper ribosomal maturation. In order to overcome this effect, the bound RbfA should be released from 30S subunit complex upon ?YjeQ binding. Surprisingly, the cells that are rescued from death are known to have point mutations at six positions in RbfA. These mutant versions of RbfA were speculated to show poor binding to ribosome. In the present study, we explain the possible role of the mutations in RbfA through in silico modeling and docking. Our results indicate that the mutations play a major role in gain of new function by the RbfA compared to the wild type RbfA protein. These findings further suggest that the point mutations weaken the efficiency of interaction of RbfA with 30S subunit thereby aiding in its release after the completion of the function.
    Review Article
    Graziele Fonseca de Sousa, Arthur Giraldi-Guimaraes, and Cintia Monteiro de Barros*
    A lot of evidence suggests the crucial role of dermatan sulfate (DS), a glycosaminoglycan (GAG) present in the extracellular matrix (ECM) of the central nervous system (CNS), in brain development, neuritogenesis, neuroprotection, and neuronal dysfunctions. Among these events, the involvement of DS during the development of the CNS has attracted attention to better comprehend its specific action in the neuroregeneration process. The variousfunctionsof DS can be mainly attributed to the structural variability of its disaccharides. Older and more recent reports about the relationship between the structure of DS and its function are helping to point out novel neurobiological roles for DS, increasing the understanding of a great range of biological functions of this molecule in the brain. Here we reviewed the recent knowledge about the function of DS, mainly in the neuritogenesis of the CNS. Furthermore, we indicate the importance of extending the in vitro and in vivo studies of the use of DS from marine organisms in the search for future therapeutic strategies.
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