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  • ISSN: 2333-7133
    Current Issue
    Special Issue on Oral Cancer
    Anderson Rocha Buelvas, DMD, MPH
    Researcher of Infection and Cancer Research Group
    University of Antioquia
    Antioquia, Colombia
    Research Article
    Árpád Péter*
    Abstract: The evidence of a strong association between chronic alcohol consumption and cancers, such as tumors of the oral cavity, pharynx, larynx and the esophagus, has existed for several years. Moreover, evidence of strong association between alcohol and cancer-related mortality is also well known. The purpose of this study was to determine the prevalence of alcohol-related mortality, cancer-related mortality and any association between the two conditions in a Hungarian village. The medical records and the cause of death of patients registered with the Clinic were analyzed retrospectively. A total 829 deaths were recorded between 1987 and 2011 (445 men and 384 women). Out of these 278 (241 men, 37 women) were alcohol-related, 211 (140 men, 71 women) were cancer-related and alcohol-related cancer deaths was 82 (76 men, 6 women). More than half of the cancer mortality cases were alcohol-related. The number of deaths caused by malignant neoplasm of the oral cavity, and the pharynx was 21 out of 82, and these occurred only in alcohol-addicted men. The data confirmed that the association between alcohol abuse and cancer is strong. Reduction in excessive alcohol consumption might be an important step in cancer prevention.
    Ludmila Halczy-Kowalik1*, Malgorzata Stecewicz2, Anna Rzewuska3, Violetta Posio4 and Dorota Margula5
    Abstract: Oral functions such as chewing, swallowing and speech can be disturbed due to a tumor proliferation that affects the tongue, and are substantially impaired after the excision of the tumor. Self-assessment of the aforementioned functions performed by the patients individually and in cooperation with the use of the functional intraoral Glasgow scale (FIGS) revealed that the functions were compromised after the excision of the tumor of higher clinic advancement in elderly patients after the excision of the anterior part of the oral cavity. Improvement of these functions after three, six and twelve months postoperative was slower in tumors with higher clinic advancement after excision with reconstruction.
    Gabriela Studer1*, Marius Bredell2, Gerhard Huber3, Stephan Studer2, and Christoph Glanzmann1
    Abstract:
    Background: In contrast to pharyngo-laryngeal cancer, definitive radiation-chemotherapy of advanced oral cavity cancer (OCC) results in inferior disease control rates. Surgery in combination with radiation +/- concomitant chemotherapy is therefore the treatment of choice for squamous cell OCC stages>/=pT1-2pN0-1. Modern intensity modulated radiation techniques (IMRT) allow more conformal dose distribution to the tumor area with consecutively less dose to surrounding normal tissues. Aim was to give a recent overview about outcome data in OCC treated in the modern IMRT era (i.e. time period since ~2000) including presentation of the own single institution results.
    Methods: our OCC IMRT cohort was evaluated with respect to disease control and radio-osteonecrosis (RON) as most seriouslate term effectfollowingradiation.
    Results: 202 OCC patients treated between 10/2002-10/2013 with a follow up of mean 30months (3-124) were assessed. 5-year overall and distant metastasis free survival, local and nodal control rates for postoperatively (n=147(73%), 60-66Gy tumor dose) vs definitively (n=55 (27%), 70Gy) irradiated patients was 70vs36% (p<0.0001) and 84%vs84% (p=0.2), 70%vs40% (p<0.0001) and 83%vs70% (p=0.006), respectively. The incidence of RONgrade 1-2was 3% (:12/147 (9%) in postoperative, 1/55 (2%)in definitive IMRT); 1grade 3 RON was observed after post IMRT dental implants. In all grade 1-2 RON, restitutioadintegrum was achieved after conservative treatment or limited surgery (debridment/decortication/sequestrectomy).
    Conclusion: Disease control and survival following combined postoperativeMRT are significantly higher than after definitive IMRT(-chemotherapy). The RON incidence revealed being higher in the operated subgroup.
    Short Communication
    María Luisa Paparella1*, Daniel Brandizzi2, Eduardo Santini-Araujo3, Rómulo Luis Cabrini4
    Abstract: The aim of this work is to report the histopathological features of jaw bone in 24 cases of bisphoshonate-related osteonecrosis of the jaw. In all cases, lamellar bone trabeculae were thicker (bone sclerosis), had no osteocytes in the lacunae (bone necrosis), and exhibited a Paget-like structure with marked signs of bone remodeling and formation of multiple trabecular compartments that were not connected to the trabecular surface. The Paget-like trabecular structure would result in a loss of trabecular vitality and in the onset of an inflammatory process due to microbial invasion. Bisphosphonate-related osteonecrosis of the jaw would initially be an aseptic process and osteomyelitis would develop after microbial infection. The results obtained from this series of cases would seem to confirm that bisphosphonates cause Paget-like bone regeneration, which would explain the likely aetiopathogenic mechanism and the association between bisphosphonate administration and the development of necrosis with secondary infection.
    Review Article
    Anderson Rocha Buelvas*
    Health inequality is the generic term used to designate differences, variations, and disparities in the health status of individuals and population groups. According to the definition proposed by the World Health Organization, health inequity implies that inequalities are unnecessary, avoidable and unjust. One of the determinants that have more impact on inequalities in oral health is inequality in access to health services, in different studies highlighting the barriers to health as the most relevant. WHO believes that there is equity in the services when warranted: 1) equal access to the services available to same needs, 2) use equal for equal needs and 3) equal for all.
    NJM Agar and RS Patel*
    Abstract: Oral cavity Squamous Cell Carcinoma (SCC) is common, and despite its relative ease of detection, patients continue to present with late stage disease. The World Health Organisation (WHO) has urged member states to involve primary care givers (dentists and general practitioners) in increasing early referral for suspicious oral lesions.
    Tobacco and alcohol consumption remain the two major risk factors for oral SCC. A brief screening history to identify high-risk individuals, followed bya simplebut thorough oral examination is the best tool available for screening for oral SCC. This is both cost effective and reduces mortality when applied to patients in high-risk groups.
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