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  • ISSN: 2379-089X
    Current Issue
    Volume 6, Issue 1
    Research Article
    Mamdouh S. Masoud, Alaa E. Ali, Gehan S. Elasala, and Gomaa E. Amer*
    Nine complexes of trimethoprim with some transition metals [Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)] were synthesized and characterized by elemental analysis, IR, electronic spectra and magnetic measurements. The IR spectra proved that trimethoprim act as a bidentate ligand. From the electronic spectra and magnetic measurements, all complexes have octahedral geometry. The antimicrobial activity examined against two gram-positive and two gram-negative bacteria. The complexes showed a well antifungal activity. The thermal decomposition mechanisms of trimethoprim and its metal complexes were studied and suggested from the DTA and TGA curves. All complexes were thermally decomposed and ended by formation of the metal oxides except the complex of mercury.
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