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  • ISSN: 2378-9409
    Volume 3, Issue 1
    Research Article
    Calero-Garcia MJ*, Calero MD, Navarro E, Ortega AR and Campos A
    Introduction: Increased life expectancy produces more dependency and deterioration in the population; in many cases more years of life are not accompanied by a good quality of life. One of the most frequent causes reduced quality of life in the elderly is the same hospitalization for acute suffering some pathology. In this context, one especially significant phenomenon in gerontology research is the loss of functionality, characterized as the loss of independence and increased cognitive decline, sometimes associated with increasing number of drugs, comorbidity complications during the hospital stay or some of the chronic diseases that have the elderly person as cardiac arrhythmias or artery hypertension.
    Objective: Specifically, the main objective of this study is to analyze to what extent biomedical and clinical factors (complications, morbidity and polypharmacy and chronic diseases) is a moderating variable in the functional y cognitive recovery of older adults hospitalized. The starting hypothesis is that there will be a significant association between this factors clinicos and cognitive recovery both at the time of hospital release as well as in the medium term (3 months after). Method and instruments: The participants were 259 elderly people, 78.4% women and 21.6% men, admitted to the Hospital Neurotraumatologico in Jaen (Spain), evaluated at different moments in time with instruments that measure daily life activities (the Barthel Index and the Lawton Index) cognitive impairment (the phototest), review of the primary care giver and biomedical and clinical data variables, such as chronic diseases of patients diagnosed and complications during hospitalization.
    Results and Conclusions: Results show that in predictive models obtained to see the functional gain predictor is the biomedical pressure ulcers and assessment of the care giver through IQCODE. IADL predictor model is COPD together with IQCODE, biomedical variable it is appearing more predictability and in cognitive impairment it is cardiac arrhythmias and functional impairment.
    Slavica Jankovic*, Mirsad Muftic and Munib Smajovic
    Osteoporosis is a disease of locomotor system. Presence of a number of risk factors can affect development and progression of the disease. For example, physical exercise, when adopted as a lifestyle, can significantly reduce bone demineralization. Same is the case for quitting some of the "bad" habits, such as smoking and alcohol consumption. FRAX score method, a risk assessment score of having fracture in ten-year period, has been endorsed by the World Health Organization in 2008.
    Methods and materials: This study involved 71 women aged 45 to 65, who live in Croatia. Bone density (BMD) of the subjects had been measured using central densitometry (DXA).
    The objective was to determine whether the respondents who adopted physical activity as their lifestyle had a reduced risk of fractures. The assessment was performed using FRAX score. The score and the analysis for the physically active subjects have been compared against the group that does not perform physical activity (i.e. reference group).
    Results: The study has shown that for the group in which subjects adopted physical exercise as their lifestyle, the FRAX score of hip fractures and the overall score was much lower than for the subjects who did not actively exercised.
    Conclusion: Presently, the most effective approach to osteoporosis is prevention. Osteoporosis is a disease that can be strongly influenced by choice of habits: such as consumption of diet enriched with calcium, cessation of cigarette smoking and alcohol consumption, and performing of regular physical activity. Furthermore, a significant contributor in prevention of osteoporosis is early disease identification and symptoms risk assessment, e.g. via FRAX score.
    Irina Culminskaya, Alexander M. Kulminski* and Anatoli I. Yashin
    A role of non-Mendelian inheritance in genetics of complex, age-related traits is becoming increasingly recognized. Recently, we reported on two inheritable clusters of SNPs in extensive genome-wide linkage disequilibrium (LD) in the Framingham Heart Study (FHS), which were associated with the phenotype of premature death. Here we address biologically-related properties of these two clusters. These clusters have been unlikely selected randomly because they are functionally and structurally different from matched sets of randomly selected SNPs. For example, SNPs in LD from each cluster are highly significantly enriched in genes (p=7.1×10-22 and p=5.8×10-18), in general, and in short genes (p=1.4×10-47 and p=4.6×10-7), in particular. Mapping of SNPs in LD to genes resulted in two, partly overlapping, networks of 1764 and 4806 genes. Both these networks were gene enriched in developmental processes and in biological processes tightly linked with development including biological adhesion, cellular component organization, locomotion, localization, signaling, (p<10-4, q<10-4 for each category). Thorough analysis suggests connections of these genetic networks with different stages of embryogenesis and highlights biological interlink of specific processes enriched for genes from these networks. The results suggest that coordinated action of biological processes during embryogenesis may generate genome-wide networks of genetic variants, which may influence complex age-related phenotypes characterizing health span and lifespan.
    Bárbara Z. Queiroz*, Daniele S. Pereira, Renata A. Lopes, Diogo C. Felicio, Renata MFVS Jardim, Juscelio P. Silva, Nayza MB Rosa, Joao MD Dias, Rosangela C. Dias, Lygia P. Lustosa, Leani SM Pereira
    Objective: To compare pain, disability and plasma inflammatory-mediators (tumor-necrosis-factor [TNF]-alpha, soluble-TNF-receptor-1 [sTNF-R1], interleukin [IL]-1β, IL-6) between elderly women with acute low back pain (LBP) "at risk" or "without risk" for sarcopenia.
    Subjects and methods: 155 women, from the "International Back Complaints in the Elders" study, were divided into groups: "without sarcopenia" and "at risk for sarcopenia". Inflammatory-mediators were measured using enzyme-linked-immunosorbent-assays; Disability, using Roland-Morris-Disability-Questionnaire; and Pain, using McGill-Pain-Questionnaire, Numerical-Pain-Scale, and frequency.
    Results and conclusions: 52.26% elderly women were "at risk" for sarcopenia and had higher levels of sTNF-R1 (p=0.037), greater LBP severity (p=0.043), frequency (p=0.037) and disability (p=0.011) than those without risk for sarcopenia.
    Case Report
    Katrien Leyssens*, Annick D’Hooghe, and Wim Laffut
    Spontaneous, non-surgical meningitis caused by Staphylococcus aureus is a rare disease with a high morbidity and mortality. Most cases arise as a complication of neurosurgical intervention or head trauma, although some rise spontaneously. We present a case of a 76 year old woman with spontaneous hematogenous Staphylococcus aureus meningitis complicated by endocarditis.
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