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  • ISSN: 2573-1610
    Current Issue
    Volume 1, Issue 1
    Research Article
    Kanchan Dholam, Gurkaran Preet Singh*, and Pravin S Bhirangi
    In patients with free-fibular osseous reconstruction following segmental mandibulectomy, altered intra-oral anatomy leads to unusual soft tissue configuration and altered bony support. Rehabilitation of such patients is a challenging task even for the experienced prosthodontist. There are several treatment modalities advocated for such patients. A removable partial denture may be the treatment of choice. Unless managed appropriately, soft tissue contours with varied displace ability especially in reconstructed region adversely affect the support, retention and stability of such removable prosthesis. Various techniques have been proposed to record a desirable impression. The purpose of this article is to describe a novel, convenient and accurate technique of making an impression employing the mucostatic principle.
    Gul Bano*, Farheen Mir, Nahida Khan, Anup Sharma, and Nigel Beharry
    Objective: The risk of developing hyperparathyroidism (HPT) in adults after radiation exposure is higher than that of the general population. Extensive follow up guidelines of United Kingdom Children’s Cancer Study group (UKCCSG) or Scottish intercollegiate guidelines network (SIGN) do not recommend monitoring serum calcium or parathyroid hormone in patients treated for childhood malignancies.
    The aim of this study was to examine the occurrence of HPT in a cohort of survivors of childhood malignancy attending a late effects clinic after their treatment for haematological and non-haematological malignancies that included previous irradiation
    Design and methods: Study was performed in 105 patients attending a late effects clinic. These patients had received different modalities f treatment including surgery, chemotherapy, radiotherapy and bone marrow transplant for haematological and non-haematological malignancies in their childhood with. All patients had evaluation for thyroid and parathyroid disease with a clinical examination and biochemical investigations. Patients with hyperparathyroidism were treated with parathyroidectomy in the absence of thyroid disease and positive localization on imaging. This resulted in normalization of serum calcium.
    Conclusion: This data suggests that there is a significant risk of hyperparathyroidism in young females with haematological malignancies who received total body irradiation as a single fraction for bone marrow transplant.
    Review Article
    Arrangoiz R*, Cordera F, Lamberton F, Luque-de-Leon E, Munoz-Juarez M, and Moreno E
    Primary hyperparathyroidism (PHPT) arises from an unregulated overproduction of PTH from an abnormal parathyroid gland. The majority of patients who have an elevated serum calcium level have a problem in one or more of their parathyroid glands. The only definitive and curative treatment of PHPT is an operation. More than 95% of patients with PHPT are symptomatic and only the minority is truly asymptomatic. Criteria exists for the management of the asymptomatic patient but the trend is shifting towards the surgical management of all patients with this disease independent of symptoms who have a reasonable life expectancy and suitable operative and anesthesia risk. This review paper will focus on the current thinking PHTP which is one of the most common endocrine disorders seen today.
    Wu WK Ricky*, Chu SM Ellie, and Yow MN Christine
    Development of new treatment strategies is crucial for patients with Nasopharyngeal Carcinoma (NPC). NPC is one of the top ten cancers highly prevalent in Hong Kong with more than 800 new cases reported annually. The epidemiologic evidence implies that Epstein-Barr virus (EBV) infection, environmental factors and genetic factors play roles in the tumorigenesis of NPC. Conventional treatment of NPC is mainly based on chemo-radiotherapy. However, the treatment outcomes in patients with advanced stage of NPC are unsatisfactory. Photodynamic therapy (PDT) is an FDA approved cancer regime in the USA, European Union, Japan and China and could be one of novel strategies in PDT development for NPC patients. It employs a combination of light-activated photosensitiser visible light and molecular oxygen to selectively destroy the biological targets. In-depth investigation for selected PSs mediated PDT on NPC cells is still underway.
    Case Report
    Barrak HA*
    We reported a case of delayed facial palsy (DFP) after mastoid surgery in twelve years old boy. Objective: is to study the possibility of reactivation of Varicella Zoster Virus as a possible cause and to review related literatures.
    Hunter J. Underwood*, David M. Williams, and Anna Kundel
    Approximately 1.5% of all thyroglossal duct cysts contain a thyroid malignancy (most commonly papillary thyroid carcinoma), which are usually diagnosed incidentally on histopathology. However, in the rare case of thyroid cancer within a thyroglossal duct cyst that is diagnosed preoperatively, the extent of surgical resection remains variable without consensus across institutions. We therefore present a case of classical papillary thyroid cancer within a thyroglossal duct cyst that was diagnosed preoperatively and discuss the current literature and controversy regarding the management of this condition.
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