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  • ISSN: 2333-6684
    Current Issue
    Volume 6, Issue 2
    Research Article
    Reva Tripathi, Vertika Verma, Tejinder Singh, Smita Kaushik, Mala YM, and Nilanchali Singh
    Objective: To evaluate the biochemical profile of patients with severe anemia in pregnancy and to study relation between maternal and umbilical cord serum levels of iron, ferritin, cobalamin and folate.
    Methods: It is a prospective case control study with 200 pregnant women with severe anemia (Hb< 7 gm/dl) and pregnant women with no anemia (Hb>11gm/dl were recruited. Serum ferritin, folate and cobalamin were measured by electro-chemiluminescence method. Cord blood samples were collected for estimating the levels of iron, ferritin, folate and cobalamin.
    Results: Cases were divided into three groups, microcytic anemia (47%), macrocytic anemia (37.5%) and dimorphic anemia (15.5%). Mothers with iron deficiency were 37.5%, whereas cobalamin and folate deficiency were seen in 47% and 11% respectively. In women with microcytic anemia, iron and ferritin levels in umbilical cord blood were 5.54 and 19.41 times higher, respectively, than maternal serum values. However, in macrocytic anemia, cobalamin levels were only 1.22 times more in cord blood as compared to maternal serum values.
    Conclusion: Cord blood values show that fetus is able to compensate for low levels of maternal iron and folate but not for cobalamin, indicating the absence of preferential transfer of cobalamin to the fetus.
    Short Communication
    Vaughan K Williams1*, Georgia Antoniou2, Andrew Atkins3, and Anne Jackson4
    Intuitively it would be assumed that the quality of life of current paediatric haemophilia patients has improved due to treatment modalities and integrated haemophilia centre support programs. This study was performed to determine if this is indeed the case. A small number of 8-12 year old haemophilia patients were asked to fill out the Haem-o qol questionnaire. Adult haemophilia patients were also presented with the 8-12 year questionnaire and asked to fill it out as they remembered their childhood experiences. Examining the median overall ratings, the adults reported higher values. However, of the eleven subscales only four showed a statistically significant difference (p<0.05) between the children and adults (view of yourself, friends, dealing with haemophilia and global health). Quality of life has improved for paediatric haemophilia patients, with adults having a higher median value for all of the eleven subscales. Apart from sport and school where improved treatment has contributed to a better physical outcome a major area of improvement is the psychosocial interaction of the paediatric population. There are still areas where improvement can be made to increase the QoL of persons with haemophilia.
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