AbstractBackground: Sokal score prognosticates patients of chronic myeloid leukaemia at diagnosis. Its value has been tested in pre-imatinib era. We hypothesise that Sokal score is a useful prognostic tool to predict response to Nilotinib therapy.
Materia.....
AbstractAfter many years of comprehensive research of the cancer
immunity cycle, immunotherapy is getting more established and
is rapidly emerging as a powerful weapon. It is a biologic therapy
helping the immune system to fight the malignancy based on th.....
AbstractAnemia is a frequent debilitating problem, negatively affecting the quality of life of cancer patients. It is associated with poor prognosis and has been directly correlated with fatigue. Despite being more common in hematologic malignancies, anemia .....
AbstractBackground: Mixed lineage leukemia (MLL) is one of the most frequently involved genes in hematologic malignancies, in particular in some forms of acute leukemia, both lymphoblastic and myeloid. In adult ALL, MLL gene re-arrangement is found in 7% cas.....
AbstractIntroduction: Differential diagnosis of testicular haematoma is a challenge. Testicular haematoma in patients with haemophilia is still more complicate. In PWH with testicular enlargement without previous trauma, an underlying condition such as an ab.....
AbstractFIP1L1-PDGFRA fusion gene, which has been reported in patients with hypereosinophilic syndrome or hypereosinophilia associated malignancies, is an important marker that led us perform molecular targeting treatment. FIP1L1-PDGFRA fusion gene, could oc.....
Abstract Invasive fungal infections, which lead to increased morbidity and mortality, are commonly observed in patients with hematologic malignancies. Pulmonary infiltrates associated with bacterial and fungal infections are often encountered in patients wit.....
AbstractGreece is one of the few countries with high incidence of ?-thalassemia trait in which prolonged national programs for prevention and treatment were implemented.
Evaluation of treatment program in 1979, demonstrated amelioration of the main clinic.....
AbstractExtramedullary hematopoiesis is a common compensatory phenomenon to chronic hemolytic anemias. When the primary sites of hemopoiesis in the adult fail, as in hemoglobinopathies (especially thalassemia and sickle cell disease), various extramedullary .....
AbstractMYH9-related disease is an autosomal dominant hereditary macro thrombocytopenia caused by mutations in the MYH9 gene which encodes the nonmuscular myosin heavy chain type IIA. The patients have mild clinical bleeding, grayish-blue inclusions in granu.....
AbstractThere is little data for the management of patients with mild hemophilia-A and inhibitors concerning prophylaxis before operations and in the postoperative period. We report a case of an adult with mild hemophilia-A and a low-titer inhibitor who succ.....
AbstractHemosuccus pancreaticus (HP) is a rare cause of upper gastrointestinal bleeding. Case of haemophilia A presenting as HP has not been reported. We describe the case of a 50 year old patient, who presented with complaints of melena, he was initially di.....
AbstractThe inherited platelet disorders are heterogenous and rare diseases. These disorders are normally associated with bleeding diasthesis due to either a platelet functional abnormality or haemostatic procoagulant defect. They can be classified into mole.....
AbstractPediatric CML’s as such is a rare entity and pediatric CML’s presenting with blast crisis at initial presentation is even rarer. We report 3 cases of pediatric CML in blast crisis at initial presentation.
AbstractBackground: Blood transfusion is an essential element of health care which saves life. As a result of the advances in clinical sciences and population increase, the need for blood is growing day by day all over the world. One percent of the populatio.....
AbstractDespite many advances in the medical field, the proper diagnosis and management of anemia, iron deficiency anemia (IDA) in particular seems elusive. Anemia in Malaysia is significant with 20.0% - 39.9% prevalence and this translates to excessive burd.....
AbstractPrimary non-secretory Plasma cell leukemiaisa rare diagnosis with only few cases reported so far. Here we report a case of a non secretory Plasma cell leukemia diagnosed on flow cytometry, as atypical morphology and negative serum and urine protein e.....
AbstractThe concurrence of malaria and hemoglobinopathies, observed in malaria endemic regions, reflects the phenomenon of natural selection. The incidence of alpha and beta Thalassemia is very high at the seaside locations related with malaria in the worldw.....
AbstractImmune thrombocytopenia (ITP) is a common hematologic disorder affecting both adult and pediatric patients. Pathogenesis of ITP involves 2 major mechanisms: increased platelet destruction by the immune system and abnormalities in megakaryocytopoiesis.....