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  • ISSN: 2334-1815
    Current Issue
    Volume 5, Issue 3
    Research Article
    Dai Hai Nguyen*
    In this study, superparamagnetic Fe3­O4 nanoparticles were surface coated with heparin-Pluronic (HP) for Doxorubicin (DOX) delivery. In detail, Fe3O4 nanoparticles were prepared and then coated with HP (Fe3O4@HP) conjugate by co-precipitation method. Furthermore, the formation of Fe3O4@HP was demonstrated by fourier transform infrared (FT-IR) and Powder X-ray diffraction (XRD). The superparamagnetic property of Fe3O4@HP was also showed by hysteresis loop analysis, the saturation magnetization reached 24.92 emu g-1. In addition, sizes and morphologies of Fe3O4 and Fe3O4@HP nanoparticles were spherical shape with average diameter of 19 nm as compared with Fe3O4 nanoparticles (12 nm), were determined by transmission electron microscopy (TEM). Especially, DOX was effectively loaded into the coated magnetic nanoparticles, 66.9% ± 2.7% for drug loading efficiency and slowly released up to 120 h. These results suggest that the potential application of Fe3O4@HP nanoparticles in the development of stable drug delivery system for cancer therapy.
    Javier Perez Quinones*, Oliver Brüggemann, and Carlos Peniche Covas
    Synthetic fructose chitosan (FC) was linked to DL-a-tocopherol, ergocalciferol, diosgenin and two synthetic analogues of brassinosteroids via a succinate linker by carbodiimide coupling in solution. Conjugates with substitution degrees of 5.5 to 39.0% were obtained and used for the sustained release of agrochemicals and potential anticancer drugs. FTIR and proton NMR spectroscopies confirmed the hydrophobic modification of fructose chitosan. Differential scanning calorimetry and wide-angle X-ray diffraction studies of prepared FC conjugates are also presented. The amphiphilic FC-vitamin and FC-steroid conjugates self-assembled in aqueous medium as stable and positively charged nanoparticles of 165 to 213 nm with 30 to 54.2 mV, as revealed using dynamic light scattering. Almost spherical nanoparticles of 40 to 65 nm in dried state were observed by SEM and TEM. Sustained release of linked vitamins and steroids in phosphate buffer saline solution at pH 6.0 was observed over 96 h, while almost constant release rates were perceived during the first 7 to 8 h. Brassinosteroid-N-modified fructose chitosan nanoparticles showed good agrochemical activity. These results indicated that the obtained nanoparticles might be potential drug delivery system of vitamins and steroids for anticancer and agrochemical applications.
    Ashwini G. Patil, Harshada R. Bafna, Mahesh P. More, Prashant K. Deshmukh, and Pravin O. Patil*
    In present research work graphene silver nanocomposite (rGO@AgNCs) was synthesized by using the sapodilla peel extract under the photochemical irradiation. Antibacterial potential GO@AgNCs was studied against dental pathogen viz. Bacillus pumilus, Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli, and Staphylococcus aureus.The minimum inhibitory concentration of GO and rGO@AgNCs was studied against dental pathogen in which the fabricated rGO@AgNCs exhibited highest MIC of 7.81 µg/mL against Pseudomonas aeruginosa while the least MIC of 15.62 µg/mL was observed against Staphyloccous aureus and GO exhibited highest MIC of 62.5 µg/mL against Pseudomonas aeruginosa and Staphyloccous aureus. Thus rGO@AgNCs may show to be superior antibacterial agents against dental pathogens.
    Arka Bandyopadhyay* and Debnarayan Jana
    In this first principles investigation, we have analysed the refractive indices, optical absorption and conductivity spectra of tetragonal graphene sheet and its experimentally realized substructure, the narrowest arm chair nanoribbon. It is noteworthy that, the oscillatory behaviours encountered in the optical responses are shifted towards the UV region under perpendicular polarization. The real part of refractive index spectra exhibit anisotropic nature for both the systems. This anisotropy leads to the anomalous dispersion near certain frequencies where attenuation peaks are also observed. A particular example is that, the violet light of energy 2.94 eV undergoes maximum attenuation when parallel polarized EM wave propagates through the sheet. Besides, the maximum peak position of absorption and attenuation spectra coincides for perpendicularly polarized light. In addition, the conductivity and absorption spectra show identical behaviour under a particular type of polarization. Our observations strongly support the fact that, these optically active, non-hexagonal, anisotropic materials can be used as birefringent in future nano-electronic devices.
    Review Article
    Gopal Vinothkumar, Raahulan Sivarajakumar and Veera Venkata Satyanarayana Reddy Karri*
    Skin cancer is the commonly and aggregation of the cells in one part of the skin. It is enhanced form the cells that line up along the membrane that separates the superficial layer of the skin from deep layer. The current treatment of the skin cancer includes Topical chemotherapy, surgical excision, Mohs micrographic surgery, radiation therapy, Photodynamic therapy. The limitation of skin cancer is Skin irritation at the site of treated place, Changes in the skin colour or dark pigmentation. Where nano particles is used for the delivery of a controlled and sustained dosage of a skin cancer drug through the skin over a period of time. The polymeric nano particles offers various advantages over the skin cancer increased solubility, sustain release, penetrability, specific site of action. Hence this article discusses about the pathology current treatments, limitations and role of the polymeric nano particles on skin cancer.
    Tejasa Upreti* and Senthil V
    Nanostructured lipid carrier is a novel delivery system that has shown great potential as an excellent carrier system. Skin disease treatment usually employs topical and systemic delivery with topical delivery being more preferred. The limitations of topical therapy are its lack of adherence to the application site and larger particle size of drug which makes it difficult for drugs to penetrate through the layers of skin. In Nanostructured lipid carrier formulations the drugs are in Nano range that are encapsulate in a lipid core which helps achieve localized and slow release over time. The advantage of loading drugs on nanostructured lipid carrier in terms of efficacy and formulation aspect is discussed in this review with the help of current research literary papers.
  • Current Issue Highlights
  • Principles and applications of dielectrophoresis (DEP) of biomolecules, suspended in aqueous medium, are reviewed.

    In this work, microporous TiO2 photocatalyst (IL-TiO2) with high photocatalytic performance was prepared via a sol-gel method using the ionic solvent

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