Recent Articles
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September 14, 2016 Research ArticleAbstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease ofunknown etiology characterized by death of upper and lower motor neurons. ALSis defined as amultifactorial disease causes by both environmental and geneticfactors. Several dat.....
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September 14, 2016 Short CommunicationAbstract Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid(TUDCA) are bile acids that have been shown to have a wide range of anti-apoptotic,mitochondrial stabilizing and cytoprotective properties. They have been shown to beprot.....
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September 13, 2013 Short CommunicationAbstract Huntington’s disease (HD) is an autosomal dominant neuropathology characterizedby a degenerative process in the basal ganglia (namely the striatum) and associatedwith progressive cognitive and motor dysfunctions. This neurological condition is caus.....
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September 10, 2016 Research ArticleAbstract Calcium dysregulation is strongly implemented in the pathophysiology ofneurodegenerative diseases. In amyotrophic lateral sclerosis (ALS), several findingsindicate mitochondrial Ca2+ disturbances, however data on Ca2+ handling mechanismsof the endopl.....
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September 09, 2016 Research ArticleAbstract Although several genetic mutations have been identified to cause Parkinson’sdisease (PD), the vast majority of cases are considered to be sporadic or multifactorial.Interestingly, epidemiological studies have shown that PD is more prevalent amongst.....
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August 29, 2016 Review ArticleAbstract Molecular clocks exhibit time-dependent substitutions, ts, and deletions,td, as consequences of enzymatic processing of EPR-generated quantuminformational content, keto-amino ? enol-imine, embodied within entangledproton qubit base pair superposition.....
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August 07, 2016 Short Note
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July 21, 2016 Review ArticleAbstract Huntington’s disease (HD) is an autosomal dominant neurodegenerative disordercharacterized by involuntary movement, cognitive and psychiatric disturbances.The disease is caused by an expansion of polyglutamine repeats in the N-terminaldomain of the.....
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June 11, 2016 Review ArticleAbstract Creutzfeldt-Jacob disease is a rare and fatal prion disease comprised of fourvariants: familial, sporadic, variant, and iatrogenic. Classic presenting symptoms includea rapidly progressive dementia, myoclonus, and ataxia. Misdiagnosis often occursdue.....
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February 16, 2016 Research ArticleAbstract Postural Instability (PI) is a disabling symptom in Parkinson Disease (PD). Falls aconsequence of PI impairs patients’ quality of life. Postural instability is usually a lateappearing symptom in PD. It’s usually regarded as a motor symptom but un.....
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May 20, 2016 Research ArticleAbstract Because amyloid-? (A?) is the main constituent of amyloid plaques, which arecommonly observed in patients with Alzheimer’s Disease (AD), the amyloid hypothesisassumes that A? is the main pathogen in AD. Thus, several therapeutic trials that targetA.....
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May 24, 2016 Case ReportAbstract Dementia with Lewy bodies (DLB) is a type of degenerative dementia markedby progressive cognitive decline with prominent deficits in attention, executivefunctions and visuospatial abilities, along with other features that are essential fordiagnosis o.....
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April 28, 2016 Review ArticleAbstract To appreciate the potential applications of stem cell technology inneurodegenerative diseases, including Parkinson’s disease (PD), it is important tounderstand the characteristics of the various types of stem cells. These stem cells includemesenchy.....
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April 21, 2016 Case ReportAbstract Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT)or Hashimoto’s encephalopathy is a recognized but poorly understood neurologicalcomplication of autoimmune thyroid disease. Proposed etiologies include autoimmunedemyel.....