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  • ISSN: 2333-6439
    Volume 6, Issue 1
    Review Article
    Gatien AG Lokossou*, Caroline Toudic, Evelyne J. Lozes, Lucien Davito, Amirath A. Badarou, Rene X. Perrin, and Benoit Barbeau
    Preeclampsia represents a danger to nearly 10 million pregnant women worldwide. This gestational pathology has very important consequences for preeclamptic (PE) women but also for newborns. To date, no early diagnostic tools are available for PE, resulting from the difficulties to identify the originating cause of this disease. However, researchers and clinicians are actively working on the identification of a biomarker acceptable to all. This is a challenging work as this biomarker must be able to identify pregnant women at risk of developing PE as early as possible during their pregnancy, in a non-invasive way and at low costs. The identification of early PE biomarkers will allow a better management of pregnant women at risk for PE or suspected for PE, and reduce maternal and child morbidity and mortality associated with this disease. Several molecules and genes have been identified as potential candidates over the years. However, not one of these has been unanimously accepted. This review will present the current state of research regarding the potentially best PE markers or combination of markers identified as of now.
    Tigist Getahun, Desta Workneh, Chernet Hailu, and Bosena Tebeje Gashaw*
    Introduction: Uterine rupture is a life threatening obstetric complication responsible for numerous maternal and perinatal deaths. It is a major public health problem in developing countries including in Ethiopia. This study examined the prevalence and outcomes of uterine rupture. Methods: Hospital based retrospective cross-sectional study was conducted at Wolisso St. Luke Catholic Hospital from January 1, 2009 to December 31, 2013 by abstracting information from medical records. Descriptive statistics was analyzed to determine the prevalence of uterine rupture and its outcomes using SPSS software. Result: The analysis revealed that 151 cases of uterine rupture among 14,152 deliveries, making the prevalence rate 1.07% (95% CI= 0.91, 1.25%). The majority were multi-gravid (67.8%), from rural area (96.7%), had prolonged duration of labor (63.3%), and 53.3% did not attend prenatal care. Obstructed labors due to cephalo-pelvic disproportion (42.2%), mal-presentation or mal-position (37.8%), previous cesarean scar (15.6%), instrumental deliveries (3.3%), and induction or augmentation with pitocin (1.1%) were reported as the causes of uterine rupture. With regard to obstetric management: uterine repair with bilateral tubal ligation performed for (40%), total abdominal hysterectomy (26.7%), repair only (24.4%), and subtotal abdominal hysterectomy (8.9%) of the cases. Of the total (90 women), (50%) of the women developed post-operative complications, of which anemia was the commonest (33.3%). Fetal and maternal case fatality rate was 94.4% and 4.4% respectively. Conclusion: The prevalence of uterine rupture, perinatal mortality, maternal morbidity and mortality were unacceptably high in the study institution. The commonest underlying causes of uterine rupture were obstructed labor. Therefore, obstetricians and midwives should be competent enough to prevent and detect early warning signs of uterine rupture. Moreover, improving the coverage and quality of health service would reduce perinatal and maternal morbidity and mortality as a result of uterine rupture.
    Case Report
    Salih Hattapoglu, and Mehmet Sedat Durmaz*
    Achondrogenesis is a rare autosomal recessive disorder presenting with severe shortness of limbs, incomplete vertebral ossification, barrel-like thorax, short extremities, enlarged abdomen and prominent forehead. The diagnosis of skeletal dysplasia could be done as soon as 13th week of gestation on prenatal ultrasonography (US). Early diagnosis is of utmost importance for accurate timing of termination and genetic counseling for future pregnancies. In this study, we illustrate the radiological and clinical findings of achondrogenesis type IA on a case that initially misdiagnosed as achondrogenesis type II on prenatal US at 16th week of gestation. Postmortem examination and pathological findings were also discussed in light of literature.
    Rajeswari*, Binayakdeb Barman, and Jasmine S Sundar
    Meig’s syndrome is a rare syndrome that consists of a benign ovarian tumor accompanied by ascites and pleural effusion. Elevated serum carbohydrate antigen 125 (CA 125) levels in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumors.
    Patients with Meig's syndrome have a benign disease, with good prognosis, but can also have elevated serum CA 125 levels. The authors present a case report of Meig’s syndrome with elevated CA 125 levels in a postmenopausal woman. This is a rare cause of pleural effusion, which is interesting because of its diagnosis and clinical course.
    Research Article
    Nancy Kumar* and Anjali Tempe
    Background: Hypertension is the most common disorder of pregnancy and the role of antihypertensive treatment for pregnant women with mild hypertension still remains unclear.
    Material and methods: This prospective randomized study was performed at Maulana Azad Medical College and Lok Nayak Hospitals, New Delhi for a duration of 48 months. The patients (n=139) were and omized into two groups by computer generated numbers. Group A (study group) received Alpha methyldopa and/or Labetalol and Group B (control group) did not receive any hypertensive drug but received supportive treatment. For quantitative data, Student’s t test or Mann-Whitney test was applied. A p value of <0.05 was regarded as significant. Long term clinical outcome was studied in the follow up and the data was analyzed.
    Results: In Group A (treated), 11patients (15.9%) developed severe hypertension while 20 patients (28.6%) developed severe hypertension in group B (non treated group). Ten patients in group A and19 patients in group B developed proteinuria. Although this difference approached a significant level (p= 0.076), there was no statistically significant difference in overall maternal and foetal complications in both the groups.
    Conclusion: Despite of the fact that complications of maternal and foetal outcome in the two groups did not differ significantly, we found that the treatment of mild hypertension in pregnancy showed near significant reduction of incidence of development of severe hypertension in treated group.
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