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  • ISSN: 2578-3181
    Current Issue
    Volume 2, Issue 1
    Research Article
    Ira Stark*, Jason Shames, Anne Misiura, Barrett Thomas, Daniel Hirsch, James Montgomery, Valeria Potigailo, and Jonathan Rubin
    Objective: Within our radiology department, we anecdotally observed that patients over the age of 65 with cancer demonstrated significantly less degenerative disease of the spine (DDD) compared to patients without cancer when reviewing CT scans of the abdomen and pelvis. The objective of this study is to determine if a statistical correlation exists between cancer and DDD.
    Materials and Methods: A list of subjects with CT scans of the abdomen and pelvis between January 1, 2014 and February 28, 2016 was compiled for retrospective review. Test subjects with known cancer were selected from our institution’s Tumor Board Registry and control subjects without a diagnosis of cancer were selected chronologically from our PACS system. After vetting for inclusion and exclusion criteria, the CT scans were anonymized and reviewed by three radiologists who subjectively evaluated degenerative changes of the anterior column, facet joints, and sacroiliac joints using a 4-point severity scale. Subjects were subdivided into 40-49, 50-59, 60-69, and 70-79years old age groups for comparison purposes.
    Results: Out of 164 test subjects (with cancer) and 421control subjects (without cancer), 75 test subjects and 90 control subjects satisfied the inclusion and exclusion criteria. With increasing age, the overall incidence and severity of DDD was less in the test group compared to the control group. The 70-79years-old test group demonstrated a 37% lower overall degenerative disease severity score in the anterior column compared to the control group. Overall intra observer reliability was 84%.
    Conclusions: The results support our observation that there is a significant difference in DDD in cancer patients compared to non-cancer patients. With further research and investigation, an underlying factor associated with the generation or suppression of degenerative changes may be discovered and exploited to prevent or treat cancer.
    Case Report
    Qing Xia* and Jian Min Sun
    Introduction: Fusion deformity of cervical vertebrae resulted from trauma is a rarely reported condition in the literatures. Fewer than 3 case reports have been made.  This case represents the first reported case, to our knowledge, of fusion deformity of cervical vertebrae caused after old cervical spine fracture subluxation.
    Presentation of case: We present the case of a 44-year-old woman with a history of falling down from the roof of the house and injuring the neck seven years ago, she had a severe pain of the neck, but there was no sensory and motor dysfunction of upper and lower extremities, she stayed home in the bed and rest for 3 months without surgery, but she often complaining about bilateral hands tingling and unsteady for recent one year.
    Discussion: Literature review of previously reported cases of fusion deformity of cervical vertebrae resulted from trauma revealed only 2 cases. Anterior approach surgery can eliminate compression factors directly, and it can obtain the excellent effects of the clinical decompression nevertheless, prevention is the most important.
    Conclusion: Delayed neurological deficit resulting from fused vertebrae deformity following irreducible old cervical spine fracture subluxation is an extremely rare complication. Instability of cervical spine is the essential and foremost pathogenic factors, and then, leads and aggravates the degeneration of the adjacent segments. We emphasize the importance that finding deformity and instability early and taking effective surgical treatment in a timely manner.
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