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  • ISSN: 2378-9344
    Volume 2, Issue 2
    Research Article
    Most Tanzila Khatun1,2, Subrina Jesmin1,2,3*, Naoto Yamaguchi2, Junko Kamiyama1, Shamima Akter3, Sayeeda Nusrat Sultana1,2, Majedul Islam1,2,3, Osamu Okazaki3, Satoru Kawano2, Hidechika Akashi3, Taro Mizutani2, Takashi Miyauchi2, Arifur Rahman4 and AKM Ahsan Habib4
    Abstract:
    Aims: Prevalence of non-communicable diseases is a challenging problem among menopausal women especially in a least developing country like Bangladesh. Recently, plasma levels of endothelin-1 or related molecules are reported to be associated with metabolic syndrome and its components. So we determined the circulatory level of endothelin-1 in Bangladeshi rural pre- and post-menopausal women and its association with various cardio-metabolic risk factors.
    Main methods: This study is based on a community based cross-sectional survey among 1678 rural women over the age of 15. We measured plasma level of endothelin-1 by ELISAand used multipleregressions to estimate the association between circulatory endothelin-1 level and cardio-metabolic risk factors.
    Key findings: Endothelin-1 levels were significantly higher in post-menopausal subjects than in pre-menopausal (post-menopausal vs. pre-menopausal: 3.13 ± 0.09 vs. 2.29 ± 0.05pg/ml, p=0.001). Mean values of age, systolic blood pressure, diastolic blood pressure, plasma triglyceride level, fasting plasma glucose level, and HDL cholesterol were significantly higher in post-menopause compared to pre-menopausal group (P<0.05). In both univariate and multiple regression analysis, we found that ET-1 had significant positive association withage only. Metabolic syndrome was present in 25.6% respondents and it was more prevalent among post-menopausal (39.3%) as compared to pre-menopausal (16.8%) women. Prevalence of hypertension was also greater in post-menopausal women than in pre-menopausal women (30.7% vs. 9.8%).
    Significance: The higher level of circulatory endothelun-1 level may be associated with various medical problems and events/syndromes of post-menopausal women in rural Bangladesh. Proper intervention strategies should be warranted among these high-risk subjects.
    Mustafa Bilge Erdogan1, Hakan Zor2, Ozerdem Ozcaliskan1, Onur Erdogmus3
    Abstract:
    Background: We investigated the efficacy, preoperative, postoperative and early stage outcomes of Anaconda type endovascular stent-grafts in patients who had intervention in our clinic with the diagnosis of abdominal aortic aneurysm.
    Material – Methods: During the years of 2010 and 2013, 23 patients (19 male, 4 female) had endovascular stent-graft procedure with the diagnosis of infrarenal abdominal aortic aneurysm. The mean age was 76.1 (67-82). All patients had Anaconda endovascular stent graft procedure.
    Results: The intervention was performed to all patients in angiology laboratory under the sterilization and technical conditions of a surgery room. Aortoiliac stenting was done for all patients. The mean procedural time was 70.5 (55-97) minutes. No patient required open surgery. Graft placement was successful in all patients. None of the patients died during the procedure. One patient died in early stage due to congestive heart failure and pulmonary edema. None of the patients had graft infection or aneurysmal rupture.
    Conclusions: In selected patients with abdominal aortic aneurysm, early stage mortality and morbidity of stent graft procedure are low. Procedure is technically easy to apply with high success rates. Good preoperative preparation, technically well equipped catheter laboratory and an experienced surgical team are sufficient for that.
    Mini Review
    Martha Lilia Tena Suck*
    Abstract: Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and vascular permeability. VEGF and its receptors are highly expressed in some adult tissues, such as the kidney glomerulus and choroid plexus.In the present work studied the expression of EVGF, EVGFR2, MVD (CD34) and CD15-li were performed in choroid plexus tumors. Clinicopatological and immune-histochemistry correlation. 42 cases were included, 28(47%) were choroid plexus papilloma grade I, 8 (13%) were atypical choroid plexus papilloma grade II and 6(10%) were choroid plexus carcinomas grade III according WHO classification. 37 female (62%9) and 23 were male (42%). The range of age was from 17 to 67 years (mean of 28.63±1.522), the mean of age for female was 41.42±1.465 and for male was 45.39±1.769ys. Tumor localization; supratentorial portion were 35(58%), and infratentorial region in 25(42%), 11(18%) were located in lateral ventricles, 6(10%) in III ventricle and 25(42%) in IV ventricle. The MVD-limean ± SD range of was 14.62±4.069 for females and 18.62±8.940 for male. CPP was 12.21±2.025, for ACPP was 18.75±2.053 and 29.00±4.050 for CPC. In relations ship MVD-li and EVGF immunoexpression; 17.90±3.315% negative, 16.44±8.22 weak of 12.11±.228 moderate. MVD-li and EVGFR2 immunoexpression was of 14.00±3.917 negative, weak 14.46±4.235, moderate 12.14±1.069 and strong 29.80±39.62. Recurrent tumors had aMVD of 19.17±8.052, vsnon- recurrent of 13.38±32.94. Patient's death was of 20.06±8.111 vsno patient's death of 12.97 ±3.182.There were statistical lineal association between MVD-li, CD15-li and EVGFR2 expression with tumor type and tumor side.In Conclusion we note that the MVD, EVGF, EVGFR2 and CD15 in choroid plexus tumors could be a bad predictive factor as well as a bad biological behavior.
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