Fiprofort Plus Dog (Fipronil + Methoprene) Flea Medicine for Dogs and Cats

Fiprofort Plus Dog

Brand(s): Fiprofort Plus Dog

Dosage options: 0.67ml, 1.34ml, 2.68ml, 4.02ml

Price from: $ 31.99

Start Order

Are you frustrated due to fleas and ticks leeching off our precious furry friends? Does seeing them in distress adversely affect your mood? Well, you're not alone!

A menace to the health of our dogs and cats, they are the two most common parasites causing infestations worldwide. Fleas are small but reproduce rapidly and feed on the blood of animals. They cause discomfort, and skin irritation and are carriers of various pathogens, such as tapeworm ticks. Ticks belong to the spider family and also feed on blood. Several diseases can be transmitted by a tick bite including Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, and tick paralysis.

Fleas are the most problematic during warm months, but they can be in your home all year round. Spring and summer are usually the most intense times for ticks. Adequate control of these pests helps alleviate immediate distress such as itching, skin lesions, and blood loss, and can also prevent tick-induced paralysis and allergic dermatitis. A reduction in the number of parasites can have an impact on the prevalence and transmission of vector-borne diseases.

Our team of licensed veterinarians and qualified writers publish and update insightful articles packed with valuable information refined and honed through years of experience. Our pet experts aim to bring you the most accurate information on how to keep your pets healthy and happy.

Flea Medicine for Dogs and Cats: Non-prescription

Wondering how to get rid of these aggravating little bloodsuckers and bring ease to our companions? Let us have a look at some of your options!

Non-prescription Flea Treatments for Dogs include:

  • Advantus (Imidacloprid) 30-Count Chewable Flea Treatment for Large Dogs
  • CAPSTAR (nitenpyram) Oral Flea Treatment for Dogs
  • K9 Advantix II Flea and Tick Prevention for Large Dogs

These are also available in different doses according to the weight of the dog, so choose accordingly!

Non-prescription Flea Treatments for Cats are as follows:

  • Advantage II 6-Dose Large Cat Flea Prevention
  • CAPSTAR Oral Flea Treatment for Cats
  • Catego Fast-Acting Flea and Tick Treatment For Cats/Kittens

It is always important to choose a treatment according to the weight of your cat to avoid any potential side effects./

However, if you're looking for a prescription treatment, an effective drug is Fipronil.


A broad-spectrum insecticide, Fipronil is classified in the phenylpyrazole chemical family. It works by disrupting the central nervous system which occurs by blockage of the GABAA receptor-ligand-gated ion channel and glutamate-gated chloride channels leading to hyperexcitation of the nerves and muscles of the parasites, ultimately causing death.

Fipronil for Dogs

Fipronil is not only efficient in combating ticks and fleas but also aids in the control of sarcoptic mange infestations in dogs and treats Cheyletiellosis.

How Does it Work?

Fipronil accumulates and spreads in the oils of the skin and hair after use. It is released over time (up to 1 month) and kills the parasites within 24-48 hours. Fleas begin to die 4-8 hours after application. It can take 12 hours or more for ticks to die and fall off, and for clinical symptoms to improve. They are usually killed before they bite, reducing the risk of allergic flea dermatitis and transmission of tick-borne diseases.

Fiprofort Plus Dog

Fiprofort Plus is a topical spot-on solution containing Fipronil 9.8% and Methoprene 8.8%. It can be used for all types of dogs. It is a prescription drug.

It is used to control and interrupt the flea life cycle, and eliminate the flea population, and tick infestation. It also targets the chewing of lice in dogs and puppies.

How is it Unique?

Fiprofort Plus Dog, along with Fipronil, additionally contains Methoprene, an insect growth regulator that prevents growth, prevents flea eggs from hatching, and flea larvae from developing into mature fleas. Together, they kill adult and larval fleas, flea eggs, and ticks of all stages. Interference in the central nervous system causes death.

A novel approach, this combination product provides a distinct benefit with a well-rounded, broad spectrum of activity. The safety and effectiveness of a combined spot ointment product have been demonstrated in a recent study under environmental conditions in India. Its ease of use may improve owner compliance. It showed variable efficacy against ticks (34.00 to 65.48%) and high effectiveness against fleas (100%) for one month. The results demonstrated an overall high level of efficacy and the combination eliminated the existing and prevented recurrence of infestation for four weeks.

How should I use this Medicine?

The veterinarian will consider your pet's full medical history, diagnosis, body weight, and risk assessment and will discuss your preferences and comfort before making a recommendation. Consideration of other pets living at home is vital because Fipronil is highly toxic to other species such as fish.


It is available in two forms:

  • high-volume spray
  • a low-volume spot-on.


Use the spray in a well-ventilated area. Spray the skin and coat with one hand while fluffing your pet's fur with the other. Spray on a gloved hand, then gently rub into the scalp. Avoid spraying straight onto the head or face. Do not apply to irritated skin and avoid the eyes and mouth.

Dosage: The topical spray is dosed at 1.5 to 3 ml per pound of body weight.

Spot on:

The topical treatment is applied directly to the skin. Avoid application on fur. The applicator is held upright and the tip is in contact with the skin after parting the hair between the shoulder blades or at the base of the neck. The drops are then released from the applicator, emptying their contents. Do not bathe with shampoo until 48 hours after treatment

Dosage: Based on weight pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds), and 4 ml (for dogs 89 to 132 pounds). One pipette is applied topically every 30 days

Fiprofort Plus Dog

This comes in single-use pipettes with pre-measured dosages that are administered to the skin, primarily between the shoulder blades or down the back.

Place the tip on the skin and gently squeeze in one or two spots to empty the contents onto the skin. Once applied, the natural oils on the skin distribute the medication around the body. The insecticide stays in their hair follicles and continues to be released. Do not shower with shampoo within 48 hours of use.

Dosage: Also based on the weight of the dog, pipettes are available in 0.69 ml (for dogs up to 22 pounds), 1.36 ml (for dogs 23 to 44 pounds), and 2.7 ml (for dogs 45 to 88 pounds), and 4.02 ml (for dogs 89 to 132 pounds). One pipette is applied topically every 30 days.

What if I Miss a Dose?

If you miss a dosage, administer it as soon as you recall, and then wait for the advised duration between doses.

Never give your pet more than one dose at a time or extra doses. Steer clear of using multiple products. If a monthly use has been prescribed, apply the dose as soon as you remember and begin a new monthly dosing plan.

If you are worried about missing a dose, contact your veterinarian.

Warnings and Precautions

Safety in Dogs:

If your dog has a bad reaction and you've used a topical product, bathe them right away with soap and water. Follow the instructions from the package insert and call your vet. Do NOT allow it to lick itself and keep pets apart while the product dries to prevent them from grooming each other and swallowing the drug.

Do NOT use a product on puppies unless the label explicitly states that it is safe to do so.

Hazardous to Humans:

umans can be exposed to Fipronil through contact with the skin or eyes, inhalation, ingestion, or clothing thus before application, gloves should be worn. Contact with your pet should be avoided until the medicine has dried. If it gets on your skin, thoroughly wash it off with soap and water.

Side Effects

Watch for signs of a reaction, especially if you're using the product for the first time. While generally safe and effective when prescribed by a veterinarian, any flea and tick control product has some risks and can be hazardous, especially if used incorrectly. Side effects can occur which are as follows:

  • Skin irritation
  • Itching can cause ulceration and open sores
  • Hair loss and hair changes
  • Convulsions
  • Body twitches
  • Loss of appetite
  • Lethargy
  • Excess drooling
  • Stomach upsets
  • Unsteady gait
  • Dermatitis
  • Reddening of the skin
  • Decreased fertility
  • Smaller litter size and decreased litter weight
  • Difficulty in conception
  • Increase in litter deaths
  • Alter thyroid hormone levels
  • Thyroid cancer
  • An increase in organ weight such as liver and kidney due to fipronil accumulation
  • Rarely an allergic reaction of the skin may occur.


Overdose is rare and no adverse effects have been reported even up to 5 times the dose however, the adverse reactions listed above may become more likely to appear.

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.


This is key if your dog:

  • Has a history of seizures
  • Is taking other drugs
  • Old
  • Sick or debilitated
  • A puppy (younger than 8 weeks of age)
  • Pregnant or nursing
  • Allergic to flea or tick products

In these cases, the vet might suggest you use a special comb to pick up fleas, eggs, and ticks. Drown the pests in a bowl of hot, soapy water.

Do you have a cat instead of a dog? No worries, we've got you covered as well!

Fipronil for Cats

Fipronil is used in cats as an external antiparasitic to treat and prevent infestation by ectoparasites such as fleas, lice, and ticks. It does not target internal parasites thus deworming is recommended to cover the entire antiparasitic spectrum.

Fipronil is sometimes used in conjunction with flea development inhibitors such as pyriproxyfen or methoprene to increase efficacy against fleas in immature stages.

So, what's the difference between the products for Cats and Dogs?

The difference lies in the concentration of ingredients. This strictly implies that owners should only use veterinary medicines that are appropriate for their pet's species. Giving a cat a medication prescribed for a dog can induce skin irritation, vomiting, seizures, and death.

How to apply Fipronil to Cats

Fipronil is always applied topically to the skin or cat to kill and prevent external parasites. Fleas begin to die between 4 to 8 hours after application. It may take 12 hours or longer for ticks to fall away.

For cats it is available in two formats:

  • Spray
  • spot-on (pipettes)


When using the spray, ruffle your pet's fur with one hand while spraying the skin and fur with the other. Spray it on a gloved hand and gently rub it into the head's hair.

Spray evenly over the whole body of the cat, holding the bottle 10-20 cm away from the animal. It must be massaged in after application so that it may penetrate the skin to exert its action. Allow it to dry naturally without the use of a hair dryer or towel.

Do NOT spray the spray directly on the head or face or get the product in your pet's mouth or eyes, or use it on irritated skin or wounds. Apply in a well-ventilated area.

Dosage: Each spray of this spray delivers 0.5 ml of product. Approximately 3 ml/kg is needed for short-haired cats, and up to 6 ml/kg, for long-haired cats.


When using a pipette, spread the drops by placing the tip directly onto the skin by parting the hair between your pet's shoulder blades and at the base of the neck. Squeeze the applicator to empty the contents.

Avoid contact with skin, eyes, or clothing. Wear gloves when applying and avoid contact with your pet until it is dry. If the medicine gets on your skin, wash it off with soap and water.

Do not allow your cat to lick itself and keep pets apart while the product dries to prevent them from grooming each other and swallowing the drug. Do not bathe your cat with shampoo within 48 hours after application.

Dosage: Pipettes are available in 0.5 ml with a concentration of 10 or 25% and one pipette is applied every month.

10% concentration should NOT be administered to cats less than 8 months old or weighing less than 1 kg.

25% concentration should NOT be given to cats under 9 months of age or weighing less than 1 kg.

Treatment Frequency:

For fleas and biting lice, all cats in a household should be treated at the same time. It is important to treat all household cats if any pet is allergic to fleas. For ticks, treatment of ONLY the affected cat is recommended.

Do not apply for more than 30 days.

Side Effects

Unfortunately, cats may lick the application spot as they are compulsive groomers. Adverse reactions typically show fairly quickly, so it is necessary to keep an eye on your cat for the first few days after application as it may cry out in distress.

Fipronil is not lethal if ingested but may cause the following side effects:

  • Hypersalivation
  • Vomiting
  • Dandruff
  • Skin irritation
  • Itching which may lead to ulcers
  • Hair loss and hair changes
  • Reddening of the skin
  • Ataxia
  • Tremors
  • Lethargy
  • Seizures
  • Difficulty breathing


In cats older than 9 weeks and weighing 1 kilogram, no adverse effects were reported. However, the risk of adverse effects may increase in case of overdose.

Fipronil poisoning in cats is hazardous and needs veterinarian care to remove or neutralize the toxin.


This is vital if your cat:

  • Is younger than 8 weeks of age
  • Weighs less than 1 kg.
  • Is sick or debilitated
  • Recovering from an illness
  • Is hypersensitive to flea or tick products
  • Is pregnant or breastfeeding.
  • Is taking other medication.
  • Has a history of seizures

The Final Verdict

The control of ticks and fleas is important for the prevention of zoonotic diseases and for the health and comfort of our beloved buddies.

The combination of Fipronil and Methoprene in Fiprofort Plus offers a wide spectrum of efficacy against fleas and ticks in infested dogs.

Fipronil-containing products are generally safe to use in healthy dogs and cats at the recommended dose and when properly administered. Following the manufacturer's guidelines is essential thus label directions should be promptly followed. Explicitly avoid using in other animal species.

Copyright © 2016 JSciMed Central All Rights Reserved
Creative Commons Licence Open Access Publication by JSciMed Central is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at Permissions beyond the scope of this license may be available at