Abstract In immune-sensitive children, repeated exposure to natural rubber latex (hevea brasiliensis proteins) can cause severe allergic manifestations of atopy, increased expression of neurotrophins, increased immunometabolism, hypoxia, cytokine overexpression, anaphylactic shock, and atypical behavioral/cognitive development. Infant products manufactured with natural rubber latex include pacifiers, bottle nipples, teething toys, and vaccines. This review presents FDA and CDC natural rubber latex guidelines and suggests exclusionary measures to decrease the incidence of maladaptive immunity and allergy-induced regressive autism