D2-40 and Collagen IV: Effective Diagnostic Markers for Acquired Reactive Perforating Collagenosis - Abstract
Reactive perforating collagenosis (RPC) is a rare perforating dermatosis characterized by transepidermal elimination of collagen fibers. The disease subsets are mainly divided into acquired reactive perforating collagenosis (ARPC) and inherited reactive perforating collagenosis (IRPC). ARPC is misdiagnosed easily due to its low incidence and similar clinical manifestations to a variety of skin diseases. The purpose of this study was to improve the diagnostic accuracy of ARPC through multiple histochemical methods and to find the specific expression of biomarkers. A deep analysis by immunohistochemical and histochemical methods applied on four ARPC patients in Zhongnan Hospital of Wuhan University in the 2021. We found that the main pathological component in ARPC is collagen type IV, which provides new clues for the pathogenesis of this disease. On the basis of this finding, we observed that D2-40 is an effective marker for the ARPC. Our results illustrate the important role of different histochemical staining techniques in the differential diagnosis of penetrating diseases. In this study, we further confirmed that collagen type IV penetrates the skin surface in APRC and the D2-40 was an effective diagnosis marker for ARPC, which provides new clues for its research and treatment.