Immunopathogenesis of Psoriasis - Abstract
The immunopathogenesis of psoriasis involves complex interactions between the innate
and the adaptive immune system. The central role for the TNF-?/IL-23/IL-17 pathway in the
immunopathogenesis of plaque psoriasis has led to the development of successful therapies
targeting these cytokines. Therefore, the knowledge of the main cells and cytokines involved in
the pathogenesis of psoriasis is essential for dermatologists to understand better the disease as
well as the mechanism of action of the biological therapies that have been revolutionizing the
treatment of psoriasis in the last two decades. In this review the main and current knowledge of
the immune pathogenesis of psoriasis is summarized.