Histopathological Tumour Component Analysis in Testicular Mixed Germ Cell Tumours: A 10-Year Series - Abstract
Objective: In this study, we examined histopathologically the tumour components or combinations of these components and analysed to changes of pathological findings with aging in the patients diagnosed with testicular mixed germ cell tumour (MGCT) in the last 10 years.
Materials and methods: 207 patients who underwent radical inguinal orchiectomy due to testicular cancer between 2010 and 2019 were retrospectively reviewed and 107 cases with MGCT whose data were fully available were included in the study. Age, primary tumour localization, primary tumour size, histopathological components and combinations of these components were analyzed. To compare the change of tumour components with aging, patients were divided into two groups according to patients’ age, Group 1 was younger than 25 years of age and group 2 was ? 25 years old.
Results: The mean age of the patients was 24.67 ± 4.31 years. Tumour component of MGCT included embryonal carcinoma in 87 patients (81.3%), teratoma in 72 patients (67.3%), yolk sac carcinoma in 66 patients (61.7%), choriocarcinoma in 17 patients (15.9%) and seminoma in 44 patients (41.1%). Current combination of these tumours was analyzed and the most common combination was found as embryonal carcinoma + teratoma + yolk sac carcinoma in 26 patients (24.3%) and the second most common combination was found as embryonal carcinoma + seminoma in 17 patients (15.9%). The incidence of three or more components was significantly higher in group 2 (57.8%) than in group 1 (51.6%) (p<0.05). The mean follow-up of the patients was 43.37 months (3-113) and 2 patients died for testicular cancer in follow-up period.
Conclusion: In 10-year series, the most common MGCT component was found as embryonal carcinoma and teratoma, while the most common combination was embryonal carcinoma + teratoma + yolk sac carcinoma. Combination of three or more components in MGCT may be more reported with increasing age (especially over 25 years old).