The objective of the present paper is to see the effectiveness of Pranayama on mental health. Three authors reviewed the research studies that explored the effects of pranayama on mental health. Systematic review was carried out by the three authors independently according to Preferred Reporting Items for Systematic Reviews and Meta-analysis Guidelines through the database i.e., Shodhganga, Scopus, PubMed and Embase. Article published until 31st July, 2025 were included. Out of 28 papers initially selected papers, 15 research papers were finally chosen for review that fitted with the inclusion criteria of the present study. The studies under the present review revealed significant positive effect of pranayama-based practices in mental health. Such effect is unanimously seen in all studies that employed different kinds of pranayama-based practices such as Bhastika, Nadisuddhi, Ujjawi, Bhramari, Kapalbhati. The results of the present review identify pranayama to be a very effective holistic health practice that can ensure wellbeing and enduring happiness in man.