Mesenchymal Stem Cell Treatment Improves Renal Failure and Multiple Episodes of Nephrolithiasis - Abstract
It is difficult to regenerate or recover kidney function once it has been compromised. Once compromised this can lead to nephrolithiasis and renal failure. Mesenchymal stem cells (MSCs), are the prime candidate for regenerative medicine and cell therapy. This case report describes a 58-year-old male with a history of recurrent nephrolithiasis, decreased estimated glomerular filtration rate (eGFR), elevated blood urea nitrogen (BUN), and elevated serum creatinine with a concern for chronic kidney disease (CKD), stage 3 development who was treated with a total of four MSCs treatments of 5.0 × 108 MSCs per infusion over the course of two months. Post-treatment five years later revealed no recurrent nephrolithiasis and normal eGFR, serum BUN, and creatinine levels which suggest that MSCs can be a safe and effective modern treatment for CKD and nephrolithiasis.