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Featured Articles
Availability of DMD mRNA Transcripts Analysis in a patient with Dystrophinopathy having a Nonsense Mutation
Authors: Yoko Narumi, Noboru Fueki, Yukiko Hayashi, Naoko Shiba, Ichizo Nishino, Yuji Inaba, Tomoki Kosho, Yoshimitsu Fukushima and Akinori Nakamura
Journal: Journal of Neurology & Translational Neuroscience
Abstract: Nonsense mutations in the DMD gene account for approximately 15% mutations in patients with dystrophinopathy and usually result in the Duchenne muscular dystorophy (DMD) phenotype. However, less than 5% of the Becker muscular dystrophy (BMD) patients are known to carry nonsense mutations.
Feasibility and Findings from a Novel Working Memory fMRI Paradigm in Multiple Sclerosis
Authors: Nelson F and Steinberg J
Journal: Journal of Neurological Disorders & Stroke
Abstract: Functional MRI (fMRI) basic cognitive paradigms such as the n-back have been shown to detect cognitive impairment (CI) in Multiple Sclerosis (MS). The immediate memory task/delayed memory task (IMT/DMT) detects varying degrees of working memory (WM) by alternating three levels of complexity and two levels of WM delay. This paradigm has not been evaluated in MS nor validated against standard neuropsychological (NP) testing.
Dielectrophoresis of Biomolecules
Authors: David J. Bakewell, Nuria Vergara-Irigaray and David Holmes
Journal: JSM Nanotechnology & Nanomedicine
Abstract: Principles and applications of dielectrophoresis (DEP) of biomolecules, suspended in aqueous medium, are reviewed. Biomolecules include nucleic acids (DNA and RNA), proteins, carbohydrates and lipids, and vary significantly in their composition and their behavior in aqueous medium. Review of dielectric polarisability principles and DEP fundamentals, therefore, focuses on two important biomolecules of interest in today's laboratory: double stranded DNA and ideal biocolloids (nanospheres).
Therapeutic Potential of Natural Catechins in Antiviral Activity
Authors: Sha Jin
Journal: JSM Biotechnology & Biomedical Engineering
Abstract: Natural compounds have been discovered to be effective in many disease treatments. Among these compounds are epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG), two abundant polyphenolic catechins in green tea. They have been found to be able to interfere with many disease-related biochemical processes in vitro. They are capable of suppressing inflammation, tumor growth, bacterial infection, and virus infection.
Endothelin-1 is not a Mechanism of IL-17 Induced Hypertension during Pregnancy
Authors: Denise C Cornelius, Kedra Wallace, Luissa Kiprono, Pushpinder Dhillon, Janae Moseley and Babbette LaMarca
Journal: Medical Journal of Obstetrics and Gynecology
Abstract: Preeclampsia is characterized as new onset maternal hypertension and proteinuria after 20 weeks gestation. Studies suggest that endothelin (ET-1) is a regulator of vascular function in preeclampsia and plays a major role in mediating chronic reduction in uterine perfusion pressure (RUPP)-induced hypertension. We recently demonstrated a role for the autoimmune cytokine interleukin 17 (IL-17) in causing placental oxidative stress and hypertension during pregnancy. In this current study...
Identification and Functional characterization of an Alternative 5' Exon of the Sodium Dependent Ascorbic Acid Transporter SLC23A1
Authors: Mandana Amir Shahagi, Hongbin Tu, Natalia Yurkova, Mark Levine and Peter Eck
Journal: Journal of Human Nutrition and Food Science
Abstract: Since the initial description of the human SLC23A1 transcript, encoding a sodiumdependent ascorbic acid transporter, no alternative splice variant had been described. In this report we describe a novel human specific alternative first exon which is located 1078 nucleotides 5' of the canonical first exon.
Effect of Light Curing Tip Distance and Immersion Media on the Degree of Conversion, Sorption and Solubility of Methacylate and Silorane-Based Composites
Authors:Diogo de Azevedo Miranda, Nubia Pavesi Pini, Glaucia Maria Bovi Ambrosano, Flavio Henrique Baggio Aguiar, Debora Alves Nunes Leite Lima and Jose Roberto Lovadino
Journal: JSM Dentistry
Abstract: The purpose of this study in vitro was evaluate the degree of conversion (DC%), sorption (Sp) and solubility (Sl) of a methacrylate composite (Filtek™ Z250) and silorane-based composite (Filtek™ P90)...
    Authors: Tea Laakso1*, Mauri Aalto2, Anna-Maija Koivisto3, Satu Männistö4 and Kaija Seppä5
    Authors: Wael Abu Dayyih1*, Dania El Tannir1, Eyad Mallah1, Mohammad Hamad2, Nasir Idkaidek3, Riad Awad1, Abdel Fatah Salem4 and Tawfiq Arafat1
    Authors: Jianjun Hu1,2#*, Yixuan Wang1 and Shaorong Gao1#*
    Authors: Timothy M. Morgan* and L. Douglas Case
    Authors: Dario Sisto1, Nicola Lavermicocca2, Donato Errico3 and Dario Rusciano4*
    Authors: Aleksandra Kuczmarska1*, Megha D. Patel1 and Nalini Mehta2
    Authors: Qiaodan Zheng1,2#, Xiang Li2#, Manjula Sunkara3, Andrew J. Morris3, Wenyuan Wu1* and Cai Huang2,4*
    Authors: Nicholas V Mendez1#, Jeffrey A Wharton1#, Jenna L Leclerc1, Spiros L Blackburn2, Martha V Douglas-Escobar3, Michael D Weiss3, Christoph N Seubert1 and Sylvain Doré1,4*
    Authors: Andre M. Vale1, Alberto Nobrega1 and Harry W. Schroeder Jr.1,2*
    Authors: Andrea L Johnstone, Claes Wahlestedt and Jose P Silva*
    Authors: Herway ST* and Benumof JL
    Authors: Lamia Nahar and Indika U. Arachchige
    Authors: Alabi O. Adenrele* and Esan B. Edward
    Authors: Eui Young So, Martin Kozicki and Toru Ouchi*
    Authors: Telman G, Fahoum S, Sprecher E, and Kouperberg E
    Authors: Joseph Tarsia1, Tiffany R. Chang1,2, Aimee Aysenne1, Amelia K Boehme3, Alton E. Sartor1, Karen C. Albright3-5, Ethan Arda Yalvac6, Rebecca Kruse-Jarres7, Cindy Leissinger7 and Sheryl Martin-Schild1*
    Authors: Bettina Sommer, Martina Haack, Daniel Garbe, and Thomas Brück*

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