AbstractIt is often difficult to facilitate the translation of an advanced therapy medicinal product (ATMP) slated for use in regenerative medicine from the laboratory bench into the clinic [1]. In order to allow clinical trials for such ATMPs to commence, r.....
AbstractTraumatic brain injury (TBI) is a serious public health and socioeconomic problem throughout the world. Each year, TBI contributes to a substantial number of cases of permanent disability and even death. According to CDC data, about 1.7 million TBI o.....
AbstractThe largest organ in the body, the skin conducts a wide range of functions to support and maintain human health [1,2]. The skin epidermis and its appendages (e.g., hair follicle, sebaceous and sweat glands) provide a protective barrier against physic.....
AbstractThe repairing of injured skin tissue is a fundamental biological process essential to the continuity of life. Wound repair is a complex and dynamic process which consists of inflammation, angiogenesis, and tissue formation and remodeling [1,2].
AbstractGiven the limited capacity of the central nervous system (CNS) and the heart for self-repair or renewal, cell-based therapy represents a promising therapeutic approach closest to provide a cure to restore normal tissue and function for neurological a.....
AbstractMesenchymal stem cells (MSCs) have been identified as ideal source for regenerative purposes. Over the past decade their potential to migrate, proliferate, differentiate and modulate has shown significant promise.
AbstractThe field of tissue engineering has expanded at a staggering rate. In terms of bone tissue engineering research alone this has been represented by a dozen or so manuscripts being published in 1990, increasing to almost 18,000 at the time of writing.
AbstractHeart failure is a major contributor to mortality in the United States. Many cardiomyocytes (CM) die following myocardial insult, and the post-natal mammalian heart has very limited regenerative capacity.
AbstractDiabetes mellitus represents a growing burden both on health-care expenditures and the quality of life of the afflicted individuals. Current estimates for the prevalence of diabetes indicate a global prevalence of about 285 million people [1].