The Potentiality of BRCA as a Chemo-Predictor: A Literature Review - Abstract
The recent studies have been focused for the breast cancer patients to evaluate the relationship between BRCA1 expression and the clinical outcome of chemotherapy (targeting BRCA as a chemo- predictor). Till date, ER, PR and Her2/neu represented as a molecular biomarker which is routinely being used for the treatment strategies for BC patients. Over the last few years, BRCA has been considerably marked as a novel potential biomarker which has been accumulated from several clinical data. Our aim of this study is to review the role of BRCA as a predictive biomarker to spot the chemotherapy response as well as to link the association between BRCA1 deficiency which leads to cancer cell death and the basal- like phenotype. This review is based on the association of literature review which might be helpful to fulfil the lacuna between mutations in BRCA and the chemo-predictive treatment by BRCA as a chemo- predictor to interpret whether BRCA is a predictive factor or a prognostic factor to the clinical outcome with chemotherapy.