Atiopathogenesis of Acute Diarrhoea - Abstract
Acute diarrhoeal diseases are caused by a number of bacterial, viral and parasitic microorganisms. The most important are Vibrios and Rotavirus. No structural damage occurs in the intestine of cholera patients. In the small intestine, glucose helps Sodium absorption. This is called carrier mediated absorption and paved the development of oral rehydration salt solution (ORS) and this solution saved the lives of millions of children all over the world. Vibrios and ETEC produce an exotoxin known as Cholera toxin (CT) or heat-labile toxin, LT) respectfully and are responsible for the pathogenesis of cholera and ETEC. ETEC also produces another Heat-labile toxin (LT) and this toxin also helps in outpouring of secretion in the intestine. The toxins are able to stabilize in its receptor with the help of Tcp. the etiological spectrum of acute diarrhoea varies from one place to another, as for example, cholera is much more prevalent in the developing world. LT-producing ETEC is more common in Eastern Region of India and LT mediated diarrhoea is more severe that ST mediated diarrhoea.