Chordomas; Crush Intraoperative Analysis - Abstract
Chordomas are known as rare primary malign tumours that have formed from primitive notochord remains and exhibit different epithelial properties. Morphologically they have distinct cell borders; the nucleus displays a monotony and blandness. Pleomorphsm, atypia, anaplasia and hipercromasia were minimal. Vacuoles were seen in cytoplasm. During January 1995 until June 2005, 22 surgeries of chordomas
and intraoperative crush were performed. The background was dirty with myxoid appearance, myxoid matrix growing in sheets or cord and had vacuoles showed more evidence of physaliferous cells. Chondoid chordoma showed vacuolated cells as well as other cells with eosinophilic cytoplasm and myxoid background. Singles cells were observed only in two cases and high cellularity was observed in 8 (42%) cases. Two cases were frank errors, only one had a partial correlation. The percentage of mistake was 30% and our accuracy diagnosis was 70%. The correlation with clinical details and radiological findings were helpful in improving the accuracy rate. There was no differentiation between cytomorphologic features smear of intracranial tumors vs sacrococcygeal location. Intraoperative analysis of chordomas could be helpful to have a good diagnosis and to have a better surgical resection.