Human Papilloma Virus Genotypes and Intraepithelial Neoplasia in HIV Positive and Negative Patients with External Condylomata Acuminata - Abstract
In order to identify differences in clinical, histopathology and virology data of patients with external condylomata acuminata (ECA) by HIV status, 47 HIV positive patients and 42 HIV negative patients were enrolled. Socio-demographic and clinical data was recorded. Histopathology study and HPV detection (Roche Linear Array genotyping assay) were performed. HIV positive patients were mainly single, MSM,
with history of STI, multiple sexual partners, receiving antiretroviral therapy and with recurrent peri-anal ECA. HPV-16 and HPV-61 were associated to this group while HPV-6 was found in HIV negative patients with ECA. Intraepithelial neoplasia (IEN) was found in 5.6% of patients, associated to HIV and HPV-16. We found differences in socio-demographic characteristics and HPV genotypes in patients with ECA by HIV
status. The association of high grade IEN with HIV infection makes evident the need of defined parameters as markers for early cancer diagnosis.