Vulvar Melanoma: A Case Report - Abstract
A 62-year-old female presenting with bleeding from a right vulvar lesion with bilateral enlarged inguinal lymph nodes. The lesion was pathologically proven as melanoma with a negative mutational analysis. She was started on neoadjuvant immunotherapy of ipilimumab and nivolumab for 5 months with a good response to treatment. She then underwent surgical debulking of the tumor except for an unresectable right pelvic lesion because of adhesions. The patient later was started on immunotherapy in addition to adjuvant radiotherapy for local control of the tumor. Vulvar melanoma represents 3-10% of all vulvar neoplasms. It is one of the common locations of mucosal melanoma which has a distinct molecular signature and a worse prognosis compared to cutaneous melanoma. Immunotherapy and molecular therapy have been showing promising results in these patients.