A 50-year-old man with weak left limb mobility was admitted in our hospital. Physical examination of the reproductive system showed no abnormalities. No skin rash or ulceration was observed in the penile anus. Head MR enhancement suggested multiple abnormal signals in the right basal ganglia/radiographic crown, Afterwards,benzathine penicillin G was administrated. The above symptoms of the patient were significantly remission, the left extremities no longer paralyse, and could walk in the ward. Three months later, the reexamination of the head MRI enhancement suggested occupying lesion fade away.