Cushing’s syndrome with Carcinoid Tumor: A Case Report and Literature Review - Abstract
Thymic Neuroendocrine Tumor (TNET) is rare and its incidence rate is approximately 2–5%. Carcinoid tumor of thymus with Cushing’s syndrome (CS) is a rare co-morbid condition. We report a 19-year-old girl with CS who had8-months history of 10-15 kg weight gain, acne on face and back of the hands, menstrual irregularity, depression, fatigue and fatigability, moon faces, buffalo hump, truncal obesity and cutaneous striae. Initial laboratory tests revealed a serum cortisol level of 78 ?g/DL, morning serum cortisol of 130 ?g/DL, the ACTH level of 440 pg/ml and a 24 hour urinary free cortisol level of 11000µg/24 hours. Thorax computed tomography showed a heterogeneous well defined mass measuring about 18×15 mm in the anterior compartment of the mediastinum. An extended thymectomy was performed by a median sternotomy. Report of pathologist was “Well-differentiated neuroendocrine neoplasm (Typical carcinoid tumor of thymus, grade 1) without lymphatic and vascular invasion”.