Cerebral Malaria (CM) is a severe complication of Plasmodium falciparum infection, leading to significant neurological damage and remains a major public health concern despite effective antimalarial therapies. Glycophorins are essential components of the red blood cell membrane that contribute to its structure, flexibility, and interactions with pathogens. Glycophorin A (GPA) is crucial for Plasmodium falciparum invasion during malaria, making it a key target for research aimed at preventing malaria. The other glycophorins, GPB, GPC, and GPD, also play important roles in RBC membrane integrity, blood group determination, and possibly pathogen interactions. They are also involved in the sequestration of infected RBCs in the brain during cerebral malaria. By promoting cytoadherence and microvascular obstruction, glycophorins contribute to the neurological complications of CM. Research into the role of glycophorins in malaria pathogenesis may offer new therapeutic targets for preventing or treating cerebral malaria. Understanding the functions of glycophorins is vital for advancing therapies for malaria, improving blood transfusion compatibility, and enhancing our knowledge of RBC biology.