Intraductal Oncocytic Papillary Neoplasm of the Pancreas - Abstract
Intraductal oncocytic papillary neoplasm (IOPN) is a rare subset of intraductal papillary mucinous neoplasm (IPMN). Herein, we report a case of IOPN in a 77 yearold woman with history of colonic adenocarcinoma and bilateral primary renal tumors, and we present a review of related literature. A computed tomography (CT) for follow-up of the renal tumors showed dilation of the pancreatic duct with abnormal soft tissue. The patient underwent fine needle aspiration and subsequent Whipple resection. Histologically, the tumor was entirely confined within the pancreatic duct, predominantly solid, and markedly pleomorphic with medullary-like features. The final diagnosis was IOPN. IOPN, first described in 1996, is recognized in pancreas and biliary tract. This neoplasm is typically composed of complex papillary structures and frequently associated with high-grade dysplasia. Due to the rarity of the tumor, its management and survival outcome are not well understood. The present case illustrates an IOPN composed entirely of high-grade neoplastic cells (intraductal oncocytic carcinoma) in a patient with history of clear cell renal cell carcinoma (clear cell RCC) and onocytoma.