Novel Report of a Clonal Myeloproliferative Disorder with Prominent Histiocytic Differentiation - Abstract
A previously healthy 68-year-old woman presented with constitutional symptoms and pancytopenia. A bone marrow biopsy revealed extensive infiltration by mature histiocytes with no significant cytologic atypia. The residual marrow had active trilineage hematopoiesis and no overt dysplasia in all three lineages. Initial fluorescence in situ hybridization (FISH) studies detected 20q deletion in 84.5% of the marrow cells. Additional FISH Studies on Wright-Giemsa stained bone marrow aspirate smears revealed a common 20q deletion between the histiocytes and the granulocytes, whereas the erythroid cells were negative for such a deletion. These findings suggested
that the histiocytes and granulocytes arose from the same progenitor cell and were clonal in nature.