Pilot Study to Investigate Select Haemostasis, Endocrine and Biochemical Parameters in Women who Undergo in-Vitro Fertilisation (IVF) before and after Stimulation with Follicle Stimulating Hormone (FSH) - Abstract
Synopsis: Before planning an assisted reproductive technology (ART), individual thromboembolic risk should be assessed.
Objective: A pilot study designed to investigate select haemostasis, endocrine and biochemical parameters in women who undergo IVF before and after stimulation with FSH. Blood was collected and analysed before and after stimulation.
Study Design: Tests performed included Luteinising hormone (LH), estradiol (E2), progesterone, testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), FSH, thyroid stimulating hormone (TSH), free thyroxin (FT4), protein S, protein C, antithrombin, lupus antibodies, anticardiolipin antibody (IgG and IgM), von Willebrand factor antigen, collagen binding and the following factors (F); F II, F V, F VII, F VIII, F IX, F X, F XI, F XII . Also, urinary iodine was assessed to screen for thyroid disorders.
Results: After stimulation, there were statistically significant difference in the levels of FSH, LH, E2, Testosterone, FAI, and F XI. Also, there was a significant negative correlation between E2 and FXII.
Conclusion: Before planning an ART, individual thromboembolic risk should be assessed. Our findings warrant a more comprehensive investigation in this group of patients to examine the long term effects of observed changes and their relation to a possible ovarian hyperstimulation syndrome (OHSS).