Post-Transplant Lymphoproliferative Disorder of the Pancreas, Report of a Case Localized to the Pancreatic Head - Abstract
Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of solid organ transplantation. It develops in association with immunosuppression and is usually linked to Epstein - Barr virus (EBV) infection. Risk factors for PTLD include type and duration of immunosuppression, age of the patient, and the type of transplanted organs, amongst others. This report summarizes clinico-radiologic and pathologic features in a case of pancreatic PTLD. Based on the presenting features, initial considerations in this patient included chronic pancreatitis and graft rejection. Due to intractable symptomatology, a total pancreatectomy was performed, leading
to the diagnosis of polymorphous PTLD. By clinico-radiologic criteria, there can be overlapping features between chronic pancreatitis, transplant rejection and PTLD. Histologic identification of EBV in atypical lymphoid population and genomic clonality are cornerstones of diagnosis of PTLD. Control of the disease is primarily achieved by reduction or succession of immunosuppression.