Trial in using Clostridium butyricum as Prophylactic for Salmonellosis in Broiler Chicken: Hematobiochemical, Immunological and Pathological Alterations - Abstract
Background: Salmonellosis is a severe systemic disease of chicken, that threaten the poultry industry all over the world, thus the present study was planned to reach to accurate treatment of this serious disease, in addition to study the effect of Salmonellosis on hemato- biochemical, immunological and pathological changes in broiler chicken.
Materials and methods: 100 broiler chickens (Cobb breed), one-days-old were obtained from Dakahlia Company for poultry production and divided as following: 25 birds were clinically healthy kept as control group (I), 25 birds infected with S. Gallinarum (II), 25 birds administrated Clostri-Mix and infected with S.Gallinarum (III) and 25 birds infected with S.Gallinarum strain and treated with Ciprociel (IV). Blood and tissue samples were collected for hematobiochemical, immunological and histopathological examination.
Results: The infected broiler chickens showed sever yellowish diarrhea. In addition, decrease in body weight, gain and feed consumption with significant increase in FCR. Furthermore, hemolytic anemia with leucocytosis was observed. Biochemical studies revealed a significant decrease in serum total proteins, albumin, Ca, GSH with significant increases in serum activities of ALT and AST, P, creatinine, uric acid and MDA concentration. Immunological studies clarified significant decrease in LTR, phagocytic % and index, in addition to several histological alterations in intestine, liver and kidney of the infected birds. All these disturbances were less severe in that administer Clostridium butyricum.
Conclusion: Clostridium butyricum can increase the bird immunity against Salmonellosis, which induced sever haemolytic anemia with hepatic, renal and intestinal disorders in broiler chickens.