Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely used for managing type 2 diabetes and obesity due to their profound systemic metabolic effects. However, alongside these benefits, concerns have arisen about potential dermatological side effects. Rapid weight reduction from GLP-1 RAs has been linked to loss of facial fat (“Ozempic face”), skin laxity, and an aging appearance. Evidence from human studies suggests a connection between GLP-1 RA–induced rapid weight loss and decreased collagen and elastin, reduced hydration, and even hair loss (telogen effluvium) in a subset of patients. Complementary in vitro findings suggest that these changes may result from nutritional deficiencies, elevated oxidative stress, and mitochondrial dysfunction. Emerging data indicate that methylene blue (MB), a mitochondrial-targeted redox modulator, exerts broad protective effects on skin and hair follicles by enhancing mitochondrial respiration, reducing reactive oxygen species, and stimulating collagen and extracellular matrix renewal. MB has also been shown to mitigate cellular cytotoxicity induced by metabolic stressors, including GLP-1 RAs, while promoting follicular stem cell viability and regeneration. When combined with ceramides, which restore the epidermal lipid barrier and improve hydration, MB offers a mechanistically complementary approach to address GLP-1–related skin thinning and barrier dysfunction. This review integrates recent advances on GLP-1 RA–induced dermatologic alterations with mechanistic insights into MB- and ceramide-mediated protection, proposing a novel dual-target strategy to restore dermal resilience, collagen homeostasis, and hair follicle integrity in patients undergoing GLP-1 therapy. • GLP-1 RAs can lead to visible skin aging, known as “Ozempic face”. • Hair shedding is a common but reversible side effect driven by rapid weight loss. • Underlying molecular mechanisms of GLP-1 RA on the skin and hair are multifactorial. • How antioxidants like Methylene Blue can help preserve skin and hair health during GLP-1 RA treatments is discussed.