Metabolomics Usefulness in Mosquito Borne Infectious Disease - Abstract
Metabolism is an important biological process in any living
things. The normal physiology links to normal metabolism
whereas the disease and pathology is usually related to abnormal
metabolism. Hence, understanding metabolism is a basic step for
understanding any disease. To study metabolism, the classical
way is based on the classical physiological and biochemical
approach. That approach requires times and attempt in in vitro
and in vivo studies. Due to the influx of new biomedical technology,
in silico approach becomes the new approach in medicine. The
bioinformatics is the approach based on computational approach
and is the direct way for the in silico study. There are many new
bioinformatics techniques such as genomics and proteomics. Of
several new bioinformatics, the metabolomics is the new omics
science focusing on metabolism via computational analysis of
metabolome. Metabolomics is an important new bioinformatics
technology that can be applied in medicine. The tracking on
metabolism is the main approach of metabolomics that can be
useful for diagnostic and therapeutic purpose. The application in
tropical medicine is possible. The usefulness of metabolomics in
mosquito borne infectious disease should be mentioned. Birungi
et al., mentioned for the “application of metabolomics to improve
understanding of the effect of dengue infection on endothelial
cells’ metabolome [1].” With use of metabolomics, “expressive
predominancy of amino acids, organic acids, carbohydrates,
nucleosides, lipids, fatty acids, and derivatives” can be studied
[2].