AMR, or antimicrobial resistance, is a normal but concerning phenomenon where microorganisms develop defenses against the effects of antimicrobial agents. AMR has gotten worse over the past 70 years as a result of environmental contamination, poor infection control, and the overuse and abuse of antibiotics in both human and veterinary medicine. The One Health viewpoint is used in this review to address AMR, highlighting the connections between people, animals, and the environment. Poor sanitation, improper use of antibiotics, and lax regulatory frameworks that encourage the selection of resistant strains are major contributors. Mechanisms of resistance such as enzymatic degradation, efflux pumps, and target modification are detailed, with ?-lactamase enzymes highlighted as key mediators in drug inactivation. The study also looks at ways to fight AMR, such as vaccination, better farm management, antimicrobial stewardship, and cutting-edge techniques like phage therapy. The review as a whole emphasizes the necessity of a coordinated, multidisciplinary, preventive worldwide response to stop the spread of antibiotic resistance.