Vaccine hesitancy presents a critical barrier to achieving optimal immunization coverage in developing nations, undermining efforts to combat preventable diseases. This paper identifies key drivers of vaccine hesitancy and evaluates interventions that can improve immunization rates in resource-limited settings. Cultural and structural factors contribute significantly to low vaccination rates, including widespread misinformation, entrenched cultural beliefs, and inadequate health infrastructure. Insights from qualitative studies conducted in regions such as Sub-Saharan Africa and South Asia underscore the complexity of community perceptions surrounding vaccines. These studies highlight the interplay between mistrust, accessibility issues, and socioeconomic factors influencing vaccine acceptance. Successful interventions in developing countries provide valuable lessons. Campaigns like those led by Gavi and other global health initiatives demonstrate the effectiveness of tailored strategies in overcoming resistance, such as community engagement and partnerships with local leaders. Additionally, advancements in mobile health technologies have shown promise in countering misinformation and enhancing public awareness. By leveraging SMS reminders, telemedicine, and social media, healthcare providers can improve outreach and reinforce pro-vaccine messaging. This equitable vaccination coverage aligns with Sustainable Development Goal 3 (Good Health and Well-being), highlighting the broader implications of addressing vaccine hesitancy for global health equity. Therefore, a coordinated approach that integrates cultural sensitivity, technological innovation, and robust health systems is essential for building trust and sustaining immunization access. Continued efforts to address vaccine hesitancy are crucial to achieving long-term public health resilience in low-income settings