1.1. Introduction: The objective was to conduct a systematic review of economic assessment of interventional strategies, in the prevention of frailty in elderly of 60 years and over living at home. 1.2. Methods: The keywords were searched in databases such as PubMed, ScienceDirect, Google Scholar and Embase. Articles published in English and French between 31/10/2010 and 31/12/2021 were included. The CHEERS statement reading grid was used to assess the quality of the studies in terms of economic assessments. 1.3. Results: The search had identified eleven relevant research studies, including nine randomised controlled trials and two quasi-experimental studies. Of these studies, we classified them into three programs: seven studies on frailty screening, three studies on falls prevention and one study on the analysis of drugs and treatments prescribed and delivered. According to the cost-effectiveness plan of these programs, four studies had no conclusion on economic results, three studies had a dominant strategy, less expensive and more effective and four studies had a dominated strategy, more expensive and not effective. Only 50% of the studies were of good quality. 1.4. Conclusion: Only three studies had less expensive and more effective multidimensional and interdisciplinary intervention strategies. They improved the quality of life of vulnerable elderly. The economic results were more mixed for some studies. Many methodological weaknesses were present in these studies.