We present a case of a 56-year-old female patient exhibiting overlapping features of Miller Fisher syndrome (MFS), Bickerstaff’s brainstem encephalitis (BBE) and Guillain-Barré syndrome (GBS). She experienced dizziness, diplopia and unsteady gait one week following an upper respiratory infection on day 1. On day 2, She demonstrated weakness in all extremities along with deteriorating respiratory function. By day 3, her neurological examination revealed disturbances in consciousness disturbance, ophthalmoplegia, ataxia, symmetrical weakness and areflexia. We established diagnosis of MFS on day 1, GBS on day 2 and overlapping BBE on day 3. Testing for anti-GQ1b, GM1, GD1b, GT1a, and GT1b IgG antibodies returned negative results. The patient underwent two courses of intravenous immunoglobulin (IVIG) therapy alongside treatment with methylprednisolone at a dosage of 1000 mg/day. By day 76 post treatment initiation, she was able to ambulate independently; however, tendon reflexes remained absent. Our findings support the hypothesis that MFS, GBS, and BBE represent interconnected clinical manifestations within an antibody-mediated spectrum.